Salicylic acid, methylene ester

Base Information

• Chemical Name: Salicylic acid, methylene ester
• CAS No.: 4540-66-3
• Molecular Formula: C10H8N2O2S2•MgOS•3H2O
• Molecular Weight: 288.257
• DSSTox Substance ID: DTXSID50196503
• Nikkaji Number: J555.316D
• Wikidata: Q83069545
• Mol file: 4540-66-3.mol

Synonyms:Salicylic acid, methylene ester;Methylene salicylate;4540-66-3;methylene disalicylate;Bissalicylic acid methylene ester;DTXSID50196503;Benzoic acid, 2-hydroxy-, methylene ester

Chemical Property of Salicylic acid, methylene ester

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 288.06338810
• Heavy Atom Count: 21
• Complexity: 335

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)OCOC(=O)C2=CC=CC=C2O)O

Technology Process of Salicylic acid, methylene ester

There total 4 articles about Salicylic acid, methylene ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

salicylic acid (69-72-7,25496-36-0,8052-31-1) + 1,1-dibromomethane (74-95-3) → methylene disalicylate salt (4540-66-3)

Guidance literature:

With anion exchange resin; for 5h; Heating;

Reference yield: 88.0%

potassium salicylate (578-36-9) + 1,1-dibromomethane (74-95-3) → methylene disalicylate salt (4540-66-3)

Guidance literature:

With poly(ethylene glycol)-600; In acetonitrile; for 9.5h; Ambient temperature;

DOI:10.1080/00397919708004081

Reference yield: 15.0%

dichloromethane (75-09-2) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → 4H-benzo[d][1,3]dioxin-4-one (6009-10-5) + methylene disalicylate salt (4540-66-3)

Guidance literature:

With dipotassium hydrogenphosphate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1039/c4ra01651c

upstream raw materials:

salicylic acid

1,1-dibromomethane

potassium salicylate

4H-benzo[d][1,3]dioxin-4-one

Downstream raw materials:

salicylic alcohol

methyl salicylate

Refernces

• 1、 Kavitake, Bhanudas P.,Salunkhe, Manikrao M.,Wadgaonkar, Prakash P.. "Efficient method for synthesis of methylene diesters using polyethylene glycol as a phase transfer catalyst". . p. 1703 - 1710. Retrieved 2007/10/03.