Propanoic acid, 2-bromo-, methyl ester, (S)-

Base Information

• Chemical Name: Propanoic acid, 2-bromo-, methyl ester, (S)-
• CAS No.: 62076-23-7
• Molecular Formula: C₄H₇BrO₂
• Molecular Weight: 167.002
• Mol file: 62076-23-7.mol

Synonyms:

Chemical Property of Propanoic acid, 2-bromo-, methyl ester, (S)-

Chemical Property:

• PSA: 26.30000
• LogP: 0.94280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 2-bromo-, methyl ester, (S)-

There total 10 articles about Propanoic acid, 2-bromo-, methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + (S)-2-bromopropionyl chloride (7148-74-5,52152-04-2,71425-59-7,22592-73-0) → methyl (2S)-2-bromopropanoate (20047-41-0,57885-43-5,5445-17-0,62076-23-7)

Guidance literature:

With pyridine; In chloroform; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ja107197p

Reference yield: 96.7%

3-Bromopropionic acid (590-92-1) + methyl D-lactate chlorosulfite → methyl (2S)-2-bromopropanoate (20047-41-0,57885-43-5,5445-17-0,62076-23-7)

Guidance literature:

With hydrogenchloride; hydrogen bromide; In water;

Reference yield: 87.0%

Methyl 2-bromopropionate (5445-17-0) + (3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione (205517-34-6) → methyl (2S)-2-bromopropanoate (20047-41-0,57885-43-5,5445-17-0,62076-23-7) + (2R)-methyl 2-bromopropionate (20047-41-0) + (S)-2-[(2R,5S)-5-Isopropyl-1,4-bis-(4-methoxy-benzyl)-3,6-dioxo-piperazin-2-yl]-propionic acid methyl ester + (R)-2-[(2R,5S)-5-Isopropyl-1,4-bis-(4-methoxy-benzyl)-3,6-dioxo-piperazin-2-yl]-propionic acid methyl ester

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tet.2006.05.033

upstream raw materials:

methanol

(S)-2-bromopropanoic acid

(S)-2-bromopropionyl chloride

(R)-Methyl lactate

Downstream raw materials:

methyl (2R)-2-methoxypropanoate

(-)-(S)-methyl 3,3-bis(benzyloxycarbonyl)-2-methylvalerate

(R)-2-phenoxypropanoic acid methyl ester

(R)-(+)-2-(4-methylphenoxy)propanoate

Refernces

• 1、 -. "HETEROCYCLYLAMINES AS PI3K INHIBITORS". Paragraph 1063. . Retrieved 2013/03/26.
• 2、 Mei, Yujiang,Dissanayake, Prabani,Allen, Matthew J.. "A new class of ligands for aqueous, lanthanide-catalyzed, enantioselective Mukaiyama aldol reactions". supporting information; experimental part. p. 12871 - 12873. Retrieved 2010/11/16.