20047-41-0

Basic information

• Product Name: [R,(+)]-2-Bromopropanoic acid methyl ester
• Synonyms: [R,(+)]-2-Bromopropanoic acid methyl ester;[R,(+)]-2-Bromopropionic acid methyl ester
• CAS NO: 20047-41-0
• Molecular Formula: C₄H₇BrO₂
• Molecular Weight: 167
• Mol File: 20047-41-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 145.9±8.0 °C(Predicted)
• Appearance: /
• Density: 1.496±0.06 g/cm3(Predicted)
• CAS DataBase Reference: [R,(+)]-2-Bromopropanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [R,(+)]-2-Bromopropanoic acid methyl ester(20047-41-0)
• EPA Substance Registry System: [R,(+)]-2-Bromopropanoic acid methyl ester(20047-41-0)

Safety Data

• Hazardous Substances Data: 20047-41-0(Hazardous Substances Data)

Usage

Description

[R,(+)]-2-Bromopropanoic acid methyl ester, with the molecular formula C4H7BrO2, is a colorless liquid chemical compound characterized by a pungent odor. It is recognized for its role as an intermediate in the synthesis of various pharmaceuticals and chemicals, and its flammability necessitates careful handling and storage.

Uses

Used in Pharmaceutical Synthesis:
[R,(+)]-2-Bromopropanoic acid methyl ester is used as an intermediate in the pharmaceutical industry for the synthesis of a wide range of pharmaceuticals. Its versatile chemical structure allows for the creation of diverse medicinal compounds, contributing to the development of new treatments and therapies.
Used in Chemical Synthesis:
In the chemical industry, [R,(+)]-2-Bromopropanoic acid methyl ester serves as a building block for the preparation of various organic compounds. Its reactivity and structural properties make it a valuable component in the synthesis of specialty chemicals and materials.
Used as a Reagent in Chemical Reactions:
[R,(+)]-2-Bromopropanoic acid methyl ester is also utilized as a reagent in chemical reactions, facilitating specific transformations and providing a means to obtain desired products with greater efficiency and selectivity.
Used as a Solvent in Laboratory Applications:
Due to its solubility properties, [R,(+)]-2-Bromopropanoic acid methyl ester is employed as a solvent in various laboratory applications. It aids in the dissolution of certain substances and can be used in the performance of chemical analyses and experiments.
It is crucial to note that the handling and storage of [R,(+)]-2-Bromopropanoic acid methyl ester require caution due to its flammability and potential health hazards, ensuring the safety of both individuals and the environment.

Upstream product

• 186581-53-3 diazomethane 
• 32644-15-8 (S)-2-bromopropanoic acid 
• 5445-17-0 Methyl 2-bromopropionate 
• 205517-34-6 (3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione 
• 590-92-1 3-Bromopropionic acid 
• 17392-83-5 (R)-Methyl lactate 
• 67-56-1 methanol 
• 7148-74-5 (S)-2-bromopropionyl chloride 

Downstream Products

• 54656-65-4 (S)-2-methoxypropionic acid methyl ester 
• 54656-63-2 methyl (2R)-2-methoxypropanoate 
• 10009-70-8 R-(+)-2-bromopropionic acid 
• 121486-79-1 (S)-(-)-methyl 2-nitrooxypropionate 
• 76549-05-8 methyl (2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoate 
• 17226-79-8 methyl 3-hydroxy-2-methyl-3-phenylpropanoate 
• 74254-54-9 (-)-(S)-methyl 3,3-bis(benzyloxycarbonyl)-2-methylvalerate 
• 115880-50-7 (R)-2-phenoxypropanoic acid methyl ester 
• 153545-97-2 (R)-(+)-2-(4-methylphenoxy)propanoate 
• 99210-92-1 (R)-2-(4-chlorophenoxy)propanoic acid methyl ester 
• 140146-14-1 (R)-methyl 2-(3-chlorophenoxy) propionate 
• 153546-07-7 methyl (R)-2-(3-nitrophenoxy)propionate 
• 140146-13-0 (R)-methyl 2-(2-chlorophenoxy) propionate 
• 153472-86-7 (R)-methyl 2-(4-phenoxyphenoxy)propanoate 

Relevant articles and documents

USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3K-DELTA RELATED DISORDERS

The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.

Study of the lanthanide-catalyzed, aqueous, asymmetric Mukaiyama aldol reaction

The development of efficient methods for the asymmetric Mukaiyama aldol reaction in aqueous solution has received great attention. We have developed a new series of chiral lanthanide-containing complexes that produce Mukaiyama aldol products with outstanding enantioselectivities. In this paper, we describe an optimized ligand synthesis, trends in stereoselectivity that result from changing lanthanide ions, and an exploration of substrate scope that includes aromatic and aliphatic aldehydes and silyl enol ethers derived from aromatic and aliphatic ketones.

A new class of ligands for aqueous, lanthanide-catalyzed, enantioselective Mukaiyama aldol reactions

The development of aqueous methods for generating enantiopure β-hydroxy carbonyl compounds is an important goal because these subunits compose many bioactive compounds and the ability to synthesize these groups in water has environmental and cost benefits. In this communication, we report a new class of ligands for aqueous, lanthanide-catalyzed, asymmetric Mukaiyama aldol reactions for the synthesis of chiral β-hydroxy ketones. Furthermore, we have used luminescence-decay measurements to unveil mechanistic information regarding the catalytic reaction via changes in water-coordination number. The precatalysts presented here yielded β-hydroxy carbonyls from aliphatic and aryl substrates with outstanding syn:anti ratios and enantiometric excesses of up to 49:1 and 97%, respectively.