99210-92-1Relevant articles and documents
Pesticide composition, application thereof and herbicide
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Paragraph 0045-0046, (2021/04/17)
The invention relates to the field of pesticides, and discloses a pesticide composition, applications thereof, and a herbicide, the composition contains a weeding effective amount of a component A and a component B, the content weight ratio of the component A to the component B is 1: (0.5-70), the component A is a compound 168 represented by a formula (I), and the component B is cyhalofop butyl represented by a formula (II); optionally, the composition also contains a component C as shown in a formula (III) which is described in the specification. The pesticide composition and the herbicide provided by the invention can overcome the defect that gramineous weeds such as barnyard grass, moleplant seeds, digitaria sanguinalis and leersia oryzae in a paddy field have resistance to aryloxyphenoxypropionate herbicides such as cyhalofop-butyl, can overcome the defect that phytotoxicity is easily generated to crops such as rice when cyclohexenone herbicides are used for preventing and controlling weeds, have an excellent weeding effect and have very good safety to the crops such as the rice.
Microbial deracemization of α-substituted carboxylic acids: Control of the reaction path
Kato, Dai-Ichiro,Miyamoto, Kenji,Ohta, Hiromichi
, p. 2965 - 2973 (2007/10/03)
A novel approach to preparing optically active α-substituted carboxylic acids using the whole cells of Nocardia diaphanozonaria JCM 3208 is described. When 2-phenylthiopropanoic acid and 2-methyl-3-phenylpropanoic acid were subjected to the reaction under aerobic conditions, the oxidation reaction proceeded preferentially rather than deracemization of these substrates. Herein, we report the design of reaction conditions to increase the deracemization activity in preference to oxidation reactions. In addition, we have successfully detected a metabolic intermediate in the reaction mixture of 2-methyl-3-phenylpropanoic acid, which indicates that the deracemization is a competitive reaction against the α-oxidation pathway of fatty acid metabolism.
Synthesis of chiral 1-[ω(4-chlorophenoxy)alkyl]-4-methylpiperidines and their biological evaluation at σ1, σ2, and sterol δ8-δ7 isomerase sites
Berardi, Francesco,Loiodice, Fulvio,Fracchiolla, Giuseppe,Colabufo, Nicola Antonio,Perrone, Roberto,Tortorella, Vincenzo
, p. 2117 - 2124 (2007/10/03)
Sumitomo's patented σ ligand 1-[3-(4-chlorophenoxy)propyl]-4-methylpiperidine (15), which has been claimed as agent for CNS disorders and neuropathies, and its lower homologue 12 were prepared along with related chiral (4-chlorophenoxy)alkylpiperidines. They were tested at σ1, σ2, and sterol Δ8-Δ7 isomerase (SI) sites by in vitro radioligand binding assays, to evaluate the influence of a chiral center in the alkyl chain on the selective σ1 binding relative to other σ family sites. Generally high σ1-site affinities were found, so that the chirality introduced by a methyl substitution resulted in slight differences. Nevertheless, the shorter oxyethylenic chain was beneficial to increase σ1 selectivity. However, the (-)-(S)-4-methyl-1-[2-(4-chlorophenoxy)1-methylethyl]piperidine ((-)-(S)-17) reached the highest σ1 affinity (Ki = 0.34 nM) and the best selectivity relative to the σ2 site (547-fold). Compound (-)-(S)-17 displayed also a moderate selectivity (11-fold) relative to the SI site.
