METHYL 3-(DIETHYLAMINO)PROPANOATE

Base Information

• Chemical Name: METHYL 3-(DIETHYLAMINO)PROPANOATE
• CAS No.: 5351-01-9
• Molecular Formula: C8H17 N O2
• Molecular Weight: 159.228
• Mol file: 5351-01-9.mol

Synonyms:Methyl3-(diethylamino)propanoate; Methyl b-diethylaminopropionate; NSC 92

Chemical Property of METHYL 3-(DIETHYLAMINO)PROPANOATE

Chemical Property:

• Vapor Pressure: 0.441mmHg at 25°C
• Refractive Index: 1.43
• Boiling Point: 194.5°C at 760 mmHg
• Flash Point: 65.7°C
• PSA: 29.54000
• Density: 0.929g/cm³
• LogP: 0.89130

Purity/Quality:

99%min ^*data from raw suppliers

Methyl 3-(Diethylamino)propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-(DIETHYLAMINO)PROPANOATE

There total 4 articles about METHYL 3-(DIETHYLAMINO)PROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-butylthioethyl β-diethylaminopropionate (84115-08-2) → methyl 3-(N,N-diethylamino)propionate (5351-01-9) + 2-(butylthio)ethanol (5331-37-3)

Guidance literature:

With methanol; sulfuric acid; for 6h; Heating;

Reference yield: 70.0%

methanol (67-56-1) + 2-butylthioethyl β-diethylaminopropionate (84115-08-2) → methyl 3-(N,N-diethylamino)propionate (5351-01-9) + 2-(butylthio)ethanol (5331-37-3)

Guidance literature:

With sulfuric acid; for 6h; Heating;

Reference yield: 27.0%

iodobenzene (591-50-4) + triethylamine (121-44-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(N,N-diethylamino)propionate (5351-01-9) + Methyl cinnamate (103-26-4,1754-62-7)

Guidance literature:

With oxygen; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 75 ℃; for 24h;

DOI:10.1016/S0040-4039(02)02372-9

upstream raw materials:

methanol

2-butylthioethyl β-diethylaminopropionate

diethylamine

acrylic acid methyl ester

Downstream raw materials:

N,N-diethylethylenediamine

β-Diethylaminopropionhydrazid

3-benzoyloxy-1-diethylamino-3-methyl-butane

N,N-diethyl-β-diethylaminopropionic acid amide

Refernces

• 1、 Kazantsev, O. A.,Zil'berman, E. N.,Salov, V. N.,Krasnov, V. L.,Shirshin, K. V.. "PREPARATION OF N,N-DIETHYLACRYLAMIDE FROM DIETHYLAMINE AND ACRYLATE ESTERS". . p. 1621 - 1625. Retrieved 2007/10/02.