7-CHLORO-4-QUINAZOLINOL

Base Information

• Chemical Name: 7-CHLORO-4-QUINAZOLINOL
• CAS No.: 31374-18-2
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.593
• Hs Code.: 2933990090
• Mol file: 31374-18-2.mol

Synonyms:7-Chloro-4(3H)-quinazolinone;7-Chloro-4(3H)-quinazolone;7-Chloro-4-quinazolinol;7-Chloroquinazolin-4-one;NSC 44057;4(1H)-Quinazolinone,7-chloro- (6CI,9CI);7-Chloro-3,4-dihydroquinazolin-4-one;7-Chloro-3H-quinazolin-4-one;

Chemical Property of 7-CHLORO-4-QUINAZOLINOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 251-253 °C
• Refractive Index: 1.71
• Boiling Point: 331.7 °C at 760 mmHg
• PKA: 0.36±0.20(Predicted)
• Flash Point: 154.4 °C
• PSA: 46.01000
• Density: 1.5 g/cm³
• LogP: 1.98880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

7-Chloro-4-hydroxyquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLORO-4-QUINAZOLINOL

There total 36 articles about 7-CHLORO-4-QUINAZOLINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

formamide (77287-34-4,77287-35-5,60100-09-6) + 2-Amino-4-chlorobenzoic acid (89-77-0) → 7-chloro-3,4-dihydroquinazolin-4-one (31374-18-2)

Guidance literature:

With acetic acid; diethylamine; at 150 ℃; for 2h; Product distribution / selectivity;

Reference yield: 95.0%

formamidine acetic acid (3473-63-0) + 2-Amino-4-chlorobenzoic acid (89-77-0) → 7-chloro-3,4-dihydroquinazolin-4-one (31374-18-2)

Guidance literature:

In water; Microwave irradiation;

Reference yield: 92.0%

methanol (67-56-1) + 2-amino-4-chlorobenzonitrile (38487-86-4) → 7-chloro-3,4-dihydroquinazolin-4-one (31374-18-2)

Guidance literature:

With cobalt(II) nitrate hexahydrate; tris(2-diphenylphosphinoethyl)phosphine; water; caesium carbonate; at 150 ℃; for 36h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.0c01307

upstream raw materials:

formamide

2-Amino-4-chlorobenzoic acid

2-amino-4-chlorobenzamide

orthoformic acid triethyl ester

Downstream raw materials:

N-(4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)acrylamide

N-(4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)-3-(dimethylamino)propanamide

3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

N-(4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)-3-piperidin-1-ylpropanamide

Refernces

• 1、 Leal, Emilse S.,Aucar, M. Gabriela,Gebhard, Leopoldo G.,Iglesias, Nestor G.,Pascual, María J.,Casal, Juan J.,Gamarnik, Andrea V.,Cavasotto, Claudio N.,Bollini, Mariela. "Discovery of novel dengue virus entry inhibitors via a structure-based approach". . p. 3851 - 3855. Retrieved 2017.
• 2、 Gui, Qing-Wen,He, Wei-Min,Huang, Wen-Jie,Lu, Zi-Qin,Ouyang, Wen-Tao,Teng, Fan,Xun, Changping,Yang, Hao,Zhu, Meng-Xue. "Visible-Light Photosynthesis of CHF2/CClF2/CBrF2-Substituted Ring-fused Quinazolinones in Dimethyl Carbonate". . . Retrieved 2021/12/01.
• 3、 Abdulwahab, Muhammad Kumayl,Ariffin, Azhar,Dzulkeflee, Rashidi,Heh, Choon Han,Leong, Kok Hoong,Tan, Ke Han. "In-silico Studies of the Antiproliferative Activity of New Anilinoquinazoline Derivatives Against NSCLC Cells.". . . Retrieved 2020/12/28.