2-(3-BroMopropyl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(3-BroMopropyl)-1,3-dioxolane
• CAS No.: 62563-07-9
• Molecular Formula: C6H11BrO2
• Molecular Weight: 195.056
• Hs Code.: 2932999099
• Mol file: 62563-07-9.mol

Synonyms:2-(3-Bromopropyl)-1,3-dioxolane;

Chemical Property of 2-(3-BroMopropyl)-1,3-dioxolane

Chemical Property:

• Refractive Index: 1.4780-1.4820
• Boiling Point: 88°C/10mmHg(lit.)
• PSA: 18.46000
• Density: 1.44
• LogP: 1.53440
• Storage Temp.: 0-10°C

Purity/Quality:

98% ^*data from raw suppliers

2-(3-Bromopropyl)-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-(3-Bromopropyl)-1,3-dioxolane is used as a reactant in the synthesis of compounds that act as therapeutic agents.

Technology Process of 2-(3-BroMopropyl)-1,3-dioxolane

There total 3 articles about 2-(3-BroMopropyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Ethyl 4-bromobutyrate (2969-81-5) + ethylene glycol (107-21-1) → 2-(3-bromopropyl)-1,3-dioxolane (62563-07-9)

Guidance literature:

Ethyl 4-bromobutyrate; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

ethylene glycol; With toluene-4-sulfonic acid; In toluene; at 90 ℃;

DOI:10.1021/acs.orglett.9b02018

Reference yield: 95.0%

Ethyl 4-bromobutyrate (2969-81-5) → 2-(3-bromopropyl)-1,3-dioxolane (62563-07-9)

Guidance literature:

Ethyl 4-bromobutyrate; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

With toluene-4-sulfonic acid; ethylene glycol; In benzine; dichloromethane; at 90 ℃;

DOI:10.1002/ejoc.201800118

Reference yield: 90.5%

4-bromobutyraldehyde (38694-47-2) + ethylene glycol (107-21-1) → 2-(3-bromopropyl)-1,3-dioxolane (62563-07-9)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 2.75h; Heating;

DOI:10.1021/jo00221a029

upstream raw materials:

4-bromobutyraldehyde

ethylene glycol

Ethyl 4-bromobutyrate

Downstream raw materials:

(R)-tert-butyl 5-(1,3-dioxolan-2-yl)-2-(diphenylmethyleneamino)pentanoate

(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)perhydroisoquinoline

(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

(4R,4aR,6S,7S,8aS)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-7-hydroxy-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Refernces

• 1、 Mikhael, Myriam,Adler, Sophia A.,Wengryniuk, Sarah E.. "Chemoselective Oxidation of Equatorial Alcohols with N-Ligated λ3-Iodanes". supporting information. p. 5889 - 5893. Retrieved 2019/08/26.
• 2、 Walters, Jennifer C.,Tierno, Anthony F.,Dubin, Aimee H.,Wengryniuk, Sarah E.. "(Poly)cationic λ3-Iodane-Mediated Oxidative Ring Expansion of Secondary Alcohols". supporting information. p. 1460 - 1464. Retrieved 2018/04/06.