5,12-Dihydroquinoxalino[2,3-b]phenazine

Base Information

• Chemical Name: 5,12-Dihydroquinoxalino[2,3-b]phenazine
• CAS No.: 531-47-5
• Molecular Formula: C18H12N4
• Molecular Weight: 284.32
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00400162
• Nikkaji Number: J693.749G,J11.703J
• Wikidata: Q72466242
• Mol file: 531-47-5.mol

Synonyms:531-47-5;5,12-dihydroquinoxalino[2,3-b]phenazine;7,12-dihydroquinoxalino[2,3-b]phenazine;5,14-DIHYDRO-5,7,12,14-TETRAAZAPENTACENE;Homofluorindine;SCHEMBL824454;SCHEMBL13770447;DTXSID00400162;IFXSPEWBAZHCCC-UHFFFAOYSA-N;AKOS024405859;5,14-Dihydroquinoxalino[2,3-b]phenazine;CS-0453308;FT-0669225;C15931;A853777

Chemical Property of 5,12-Dihydroquinoxalino[2,3-b]phenazine

Chemical Property:

• Melting Point: 545 °C
• Boiling Point: 431.5±45.0 °C(Predicted)
• PKA: 8.38±0.20(Predicted)
• PSA: 63.16000
• Density: 1.43
• LogP: 4.73620
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 284.106196400
• Heavy Atom Count: 22
• Complexity: 376

Purity/Quality:

99%, ^*data from raw suppliers

HomoFluorindine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)NC3=CC4=NC5=CC=CC=C5N=C4C=C3N2
• Uses: 5,12-Dihydro-5,7,12,14-Tetrazapentacene is a Fluorindine analogue. Substrate with chemiluminescence amplification for immunochemical use.

Technology Process of 5,12-Dihydroquinoxalino[2,3-b]phenazine

There total 22 articles about 5,12-Dihydroquinoxalino[2,3-b]phenazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,2-diamino-benzene (95-54-5) + p-benzoquinone (106-51-4) → 5,12-dihydro-5,7,12,14-tetraazapentacene (531-47-5)

Guidance literature:

With acetic acid; at 20 ℃;

DOI:10.1039/c8cc07529h

Reference yield: 89.0%

2,5-dihydroxy-1,4-benzoquinone (615-94-1) + 1,2-diamino-benzene (95-54-5) → 5,12-dihydro-5,7,12,14-tetraazapentacene (531-47-5)

Guidance literature:

With acetic acid; In ethanol; for 24h; Heating;

DOI:10.1039/b508594b

Reference yield:

sodium acetate (127-09-3) + 2-Chloronitrobenzene (88-73-3) + 1,2-diamino-benzene (95-54-5) → 2,3-diaminephenazine (655-86-7) + 2-nitro-2'-aminodiphenylamine (2055-56-3) + 5,12-dihydro-5,7,12,14-tetraazapentacene (531-47-5)

Guidance literature:

at 150 - 160 ℃;

upstream raw materials:

2,3-diaminephenazine

1,2-diamino-benzene

2,5-bis-(2-nitro-anilino)-[1,4]benzoquinone

o-semidine

Refernces

• 1、 Kour, Harpreet,Paul, Satya,Singh, Parvinder Pal,Gupta, Rajive. "A mild and simple method for the synthesis of substituted phenazines". . p. 495 - 500. Retrieved 2014/03/21.