Phenazine-2,3-diamine

Base Information

• Chemical Name: Phenazine-2,3-diamine
• CAS No.: 655-86-7
• Molecular Formula: C12H10 N4
• Molecular Weight: 210.238
• Hs Code.: 2933990090
• European Community (EC) Number: 211-512-0
• UNII: 0B20H27U1Y
• DSSTox Substance ID: DTXSID40984097
• Nikkaji Number: J205.948G
• Wikidata: Q27236559
• ChEMBL ID: CHEMBL274921
• Mol file: 655-86-7.mol

Synonyms:2,3-diaminophenazine

Chemical Property of Phenazine-2,3-diamine

Chemical Property:

• Appearance/Colour: WHITE TO BROWN POWDER, CRYSTALS OR. CRYSTALLINE POWDER AND/OR CHUNKS
• Vapor Pressure: 4.78E-10mmHg at 25°C
• Melting Point: >300ºC
• Refractive Index: 1.5000 (estimate)
• Boiling Point: 491 °C at 760 mmHg
• PKA: 4.24±0.30(Predicted)
• Flash Point: 282.7 °C
• PSA: 77.82000
• Density: 1.414 g/cm³
• LogP: 3.10980
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 210.090546336
• Heavy Atom Count: 16
• Complexity: 231

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Phenazinediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): XiXn
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)N=C3C=C(C(=CC3=N2)N)N
• Description: 2,3-Diaminophenazine is a brown to yellow needles. On heating sublimes forming yellow leaflets. mp 264°. Sol in alcohol, benzene. Yields 2-aminophenazine and small amounts of phenazine when heated with zinc dust.It is used for detection of bismuth, cadmium, lead, copper, and mercury.
• Uses: 2,3-Phenazinediamine is used for the study on detection of HIV-1 p24 antigen in patients with varying degrees of viremia using ELISA with photochemical signal amplication system.

Technology Process of Phenazine-2,3-diamine

There total 50 articles about Phenazine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,2-diamino-benzene (95-54-5) → 2,3-diaminephenazine (655-86-7)

Guidance literature:

With iron(III) chloride; In water; at 20 ℃; for 5h;

DOI:10.1139/v11-094

Reference yield: 78.0%

1,2-diamino-benzene (95-54-5) → 2,3-diaminephenazine (655-86-7) + 2-amino-3-hydroxy-phenazine (4569-77-1)

Guidance literature:

With hydrogenchloride; iron(III) chloride; at 20 ℃;

DOI:10.1080/10426500701415980

Reference yield: 64.3%

cyclohexa-1,4-diene (1165952-92-0) + 1,2-diamino-benzene (95-54-5) → 2,3-diaminephenazine (655-86-7)

Guidance literature:

With thorium(IV) nitrate; oxygen; In water; at 80 ℃;

DOI:10.1016/j.tetlet.2015.12.058

upstream raw materials:

benzofurazan oxide

acetic acid

1,2-diamino-benzene

o-phenylenediamine dihydrochloride

Downstream raw materials:

2,3-Bis-acetylamino-phenazin

2-(phenyl)-1H-imidazo[4,5-b]phenazine

2-(4-methoxyphenyl)-1H-imidazo[4,5-b]phenazine

5,12-dihydro-5,7,12,14-tetraazapentacene

Refernces

• 1、 Qi, Guohua,Fu, Cuicui,Chen, Gang,Xu, Shuping,Xu, Weiqing. "Highly sensitive SERS sensor for mercury ions based on the catalytic reaction of mercury ion decorated Ag nanoparticles". . p. 49759 - 49764. Retrieved 2015.
• 2、 Wu, Qing,Su, Teng,Mao, Yanjie,Wang, Qigang. "Thermal responsive microgels as recyclable carriers to immobilize active proteins with enhanced nonaqueous biocatalytic performance". . p. 11299 - 11301. Retrieved 2013.
• 3、 Dongare, Pravin R.,Gore, Anil H.,Kolekar, Govind B.,Ajalkar, Balu D.. "A Phenazine based colorimetric and fluorescent chemosensor for sequential detection of Ag+ and I? in aqueous media". . p. 231 - 242. Retrieved 2020.
• 4、 Li, Siyu,Tang, Feng,Wang, Huixin,Feng, Junran,Jin, Zhaoxia. "Au-Ag and Pt-Ag bimetallic nanoparticles@halloysite nanotubes: Morphological modulation, improvement of thermal stability and catalytic performance". . p. 10237 - 10245. Retrieved 2018.
• 5、 Gao, Ping,Sun, Xiang-Ying,Liu, Bin,Lian, Hui-Ting,Liu, Xin-Qiang,Shen, Jiang-Shan. "Cu MOF-based catalytic sensing for formaldehyde". . p. 8105 - 8114. Retrieved 2018.
• 6、 Tyagi, Nidhi,Mathur, Pavan. "Iron(III) complexes of bis (benzimidazol-2-yl) methyl) thiophene-2,5- dicarboxamide: Synthesis, spectral and oxidation of o-phenylenediamine". . p. 759 - 767. Retrieved 2012.
• 7、 Fu, Patty K.-L.,Abuzakhm, Sonia,Turro, Claudia. "Photoinduced DNA cleavage and cellular damage in human dermal fibroblasts by 2,3-diaminophenazine". . p. 89 - 95. Retrieved 2005.
• 8、 Devi, Henam Sylvia,Singh, Henam Premananda. "Unique dual responsive activity of a platinum nanozyme stabilized by a green solvent: Deep eutectic solvents". . p. 12369 - 12373. Retrieved 2018.
• 9、 He, Yi,Li, Hua,Liang, Jingkai,Wang, Junren,Yu, Haili. "Cascade Chromogenic System with Exponential Signal Amplification for Visual Colorimetric Detection of Acetone". . p. 6548 - 6554. Retrieved 2020.
• 10、 Zhu, Shuyun,Lei, Cuihua,Gao, Yue,Sun, Jing,Peng, Hongwei,Gao, Han,Zhang, Ruixue,Wang, Rui,Zhao, Xian-En,Wang, Hua. "Simple and label-free fluorescence detection of ascorbic acid in rat brain microdialysates in the presence of catecholamines". . p. 3851 - 3856. Retrieved 2018.