Technology Process of 2-[(E)-2-[(1S,2R,4aS,8aR)-1,2,3,4,4a,7,8,8a-Octahydro-1,2,4a,5-tetramethylnaphthalen-1-yl]ethylidene]butanedial
There total 8 articles about 2-[(E)-2-[(1S,2R,4aS,8aR)-1,2,3,4,4a,7,8,8a-Octahydro-1,2,4a,5-tetramethylnaphthalen-1-yl]ethylidene]butanedial which
guide to synthetic route it.
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synthetic route:
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111951-15-6
(1S*,2R*,4aS*,8aR*)-1,2,3,4,4a,7,8,8a-Octahydro-1,2,4a-trimethyl-1-vinyl-5(6H)-naphthalenone
- Guidance literature:
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Multi-step reaction with 6 steps
1: Zn-TiCl4 / tetrahydrofuran
2: KNH(CH2)3NH2, NH2(CH2)3NH2 / 5 h / Ambient temperature
3: 1.) Me2CHMe2CBH2; 2.) H2O2, NaOH / 1.) THF
4: (COCl)2, DMSO, NEt3 / CH2Cl2
5: NaH / tetrahydrofuran
6: 1.) di-i-butylaluminium hydride, Et2AlCl; 2.)1M HCl / 1.) from -78 to 40 deg C, Et2O-PhMe; 2.) THF
With
hydrogenchloride; sodium hydroxide; oxalyl dichloride; Thexylboran; dihydrogen peroxide; diethylaluminium chloride; titanium tetrachloride; potassium salt of 1,3-diaminopropane; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; Trimethylenediamine; triethylamine; zinc;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)96935-1
- Guidance literature:
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Multi-step reaction with 8 steps
1: TiCl4 / CH2Cl2, 0 deg C.
2: Raney Ni / ethanol
3: Zn-TiCl4 / tetrahydrofuran
4: KNH(CH2)3NH2, NH2(CH2)3NH2 / 5 h / Ambient temperature
5: 1.) Me2CHMe2CBH2; 2.) H2O2, NaOH / 1.) THF
6: (COCl)2, DMSO, NEt3 / CH2Cl2
7: NaH / tetrahydrofuran
8: 1.) di-i-butylaluminium hydride, Et2AlCl; 2.)1M HCl / 1.) from -78 to 40 deg C, Et2O-PhMe; 2.) THF
With
hydrogenchloride; sodium hydroxide; oxalyl dichloride; Thexylboran; dihydrogen peroxide; diethylaluminium chloride; titanium tetrachloride; potassium salt of 1,3-diaminopropane; nickel; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; Trimethylenediamine; triethylamine; zinc;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)96935-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1: KNH(CH2)3NH2, NH2(CH2)3NH2 / 5 h / Ambient temperature
2: 1.) Me2CHMe2CBH2; 2.) H2O2, NaOH / 1.) THF
3: (COCl)2, DMSO, NEt3 / CH2Cl2
4: NaH / tetrahydrofuran
5: 1.) di-i-butylaluminium hydride, Et2AlCl; 2.)1M HCl / 1.) from -78 to 40 deg C, Et2O-PhMe; 2.) THF
With
hydrogenchloride; sodium hydroxide; oxalyl dichloride; Thexylboran; dihydrogen peroxide; diethylaluminium chloride; potassium salt of 1,3-diaminopropane; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; Trimethylenediamine; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)96935-1
