N-Dimethylaminomaleamic acid

Base Information

• Chemical Name: N-Dimethylaminomaleamic acid
• CAS No.: 10191-43-2
• Molecular Formula: C₆H₁₀N₂O₃
• Molecular Weight: 158.157
• NSC Number: 201810,82238
• Nikkaji Number: J800.985F
• Mol file: 10191-43-2.mol

Synonyms:N-Dimethylaminomaleamic acid;Maleic 1,1-dimethylhydrazide;CO 11;C 011;2-Butenedioic acid (Z)-, mono(2,2-dimethylhydrazide);N'-Dimethyl-maleinsaurehydrazid;N-(Dimethylamino)maleamidic acid;Maleic acid,2-dimethylhydrazide);NSC82238;NSC-82238;NSC201810;NSC-201810;2-Butenedioic acid (Z)-,2-dimethylhydrazide);10191-43-2

Chemical Property of N-Dimethylaminomaleamic acid

Chemical Property:

• Density: 1.225g/cm³
• XLogP3: -2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 158.06914219
• Heavy Atom Count: 11
• Complexity: 186

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)NC(=O)C=CC(=O)O
• Isomeric SMILES: CN(C)NC(=O)/C=C\C(=O)O

Technology Process of N-Dimethylaminomaleamic acid

There total 2 articles about N-Dimethylaminomaleamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

maleic anhydride (108-31-6) + N,N-Dimethylhydrazine (57-14-7) → N-(Dimethylamino)maleaminsaeure (10191-43-2,20696-17-7,2573-06-0)

Guidance literature:

In diethyl ether; at 20 ℃;

DOI:10.1016/j.bioorg.2021.104969

Reference yield:

→ N-(Dimethylamino)maleaminsaeure (10191-43-2,20696-17-7,2573-06-0)

Guidance literature:

Maleinsaeureanhydrid + H2NNMe2 IV;

Reference yield:

N-(Dimethylamino)maleaminsaeure (10191-43-2,20696-17-7,2573-06-0) → 1-(dimethylamino)-1H-pyrrole-2,5-dione (10270-11-8)

Guidance literature:

With sodium acetate; acetic anhydride; at 80 - 100 ℃;

DOI:10.1016/j.bioorg.2021.104969

upstream raw materials:

maleic anhydride

N,N-Dimethylhydrazine

Downstream raw materials:

1-(dimethylamino)-1H-pyrrole-2,5-dione

Refernces