TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE

Base Information

• Chemical Name: TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE
• CAS No.: 62921-75-9
• Molecular Formula: C15H24O6S
• Molecular Weight: 332.418
• Mol file: 62921-75-9.mol

Synonyms:Ethanol,2-[2-(2-ethoxyethoxy)ethoxy]-,4-methylbenzenesulfonate;triethylene glycol monoethyl ether p-tosylate;monotosyloxy triethylene glycol monoethyl ether;triethylene glycol monoethyl ether p-toluenesulfonate;triethyleneglycol monoethyl ether tosylate;2-(2-(2-ethoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate;3,6,9-trioxaundecyl (4-methylbenzene)sulfonate;

Chemical Property of TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE

Chemical Property:

• PSA: 110.67000
• LogP: 2.37090

Purity/Quality:

2-(2-(2-Ethoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE

There total 3 articles about TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

monoethyl ether of triethylene glycol (112-50-5) + p-toluenesulfonyl chloride (98-59-9) → 2-(2-(2-ethoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (62921-75-9)

Guidance literature:

With triethylamine; at 0 - 20 ℃;

DOI:10.1002/ejoc.200800423

Reference yield: 100.0%

hydrogenchloride (7647-01-0,15364-23-5) + monoethyl ether of triethylene glycol (112-50-5) + p-toluenesulfonyl chloride (98-59-9) → 2-(2-(2-ethoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (62921-75-9)

Guidance literature:

monoethyl ether of triethylene glycol; p-toluenesulfonyl chloride; With pyridine; In diethyl ether; for 3.5h; Cooling with ice;

hydrogenchloride; In water; ethyl acetate;

Reference yield: 73.0%

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) + p-toluenesulfonyl chloride (98-59-9) → 2-(2-(2-ethoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (62921-75-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/om5006897

upstream raw materials:

monoethyl ether of triethylene glycol

p-toluenesulfonyl chloride

hydrogenchloride

2-(2-methoxyethoxy)ethyl alcohol

Downstream raw materials:

2-iodo-1,3-bis(1,4,7,10-tetraoxadodecyl)benzene

2-bromo-1,3-bis(1,4,7,10-tetraoxadodecyl)benzene

2-[2-(2-methoxyethoxy)ethoxy]ethylamine

2-(2-(2-methoxyethoxy)ethoxy)ethyl azide

Refernces

• 1、 Dressler, Justin J.,Charlesworth-Seiler, Eva M.,Dahl, Bart J.. "Synthesis of a triethylene glycol-capped benzo[1,2-c:4,5-c']bis[2]benzopyran-5,12-dione: A highly soluble dilactone-bridged p-terphenyl with a crankshaft architecture". . . Retrieved 2020/10/02.
• 2、 -. "PYRROLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF INFLUENZA VIRUS REPLICATION". Paragraph 00274. . Retrieved 2018/11/22.