4-AMINOBENZENESULPHONAMIDE HCL

Base Information

• Chemical Name: 4-AMINOBENZENESULPHONAMIDE HCL
• CAS No.: 6101-31-1
• Molecular Formula: C₆H₈N₂O₂S*ClH
• Molecular Weight: 208.669
• Mol file: 6101-31-1.mol

Synonyms:4-AMINOBENZENESULPHONAMIDE HCL

Chemical Property of 4-AMINOBENZENESULPHONAMIDE HCL

Chemical Property:

• Vapor Pressure: 1.27E-06mmHg at 25°C
• Melting Point: 311 °C (decomp)
• Boiling Point: 400.5°C at 760 mmHg
• Flash Point: 196°C
• PSA: 94.56000
• LogP: 3.08050
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

4-Aminobenzenesulfonamidehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINOBENZENESULPHONAMIDE HCL

There total 3 articles about 4-AMINOBENZENESULPHONAMIDE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

2-chloro-N-(4-sulfamoylphenyl)acetamide (14949-01-0) → sulfanilamide hydrochloride (6101-31-1,34612-79-8)

Guidance literature:

With thionyl chloride; In methanol; for 0.5h; Reflux;

DOI:10.1007/s11164-011-0327-6

Reference yield: 99.5%

p-acetylaminobenzenesulfonamide (121-61-9) → sulfanilamide hydrochloride (6101-31-1,34612-79-8)

Guidance literature:

With thionyl chloride; In methanol; for 2.5h; Reflux;

DOI:10.1007/s11164-011-0327-6

Reference yield:

sulfanilamide (63-74-1) → sulfanilamide hydrochloride (6101-31-1,34612-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 0 - 15 °C

2: thionyl chloride / methanol / 0.5 h / Reflux

With thionyl chloride; potassium carbonate; In methanol; acetone;

DOI:10.1007/s11164-011-0327-6

upstream raw materials:

2-chloro-N-(4-sulfamoylphenyl)acetamide

sulfanilamide

p-acetylaminobenzenesulfonamide

Downstream raw materials:

4-isothiocyanatobenzene sulfonamide

4-[(5-Oxazol-5-yl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-amino]benzenesulfonamide

2-phenoxy-N-(4-sulfamoylphenyl)acetamide

(4-aminosulfonylphenyl)thiourea

Refernces