Technology Process of Benzamide, 3-fluoro-4-hydroxy-N-methyl-
There total 5 articles about Benzamide, 3-fluoro-4-hydroxy-N-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol; water;
at 20 ℃;
for 64h;
under 2585.81 Torr;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone / 18 h / Reflux
2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h
2.2: pH 3 / Cooling with ice
3.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 20 h / 0 - 20 °C
3.2: 18 h / 20 °C
4.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 64 h / 20 °C / 2585.81 Torr / Inert atmosphere
With
thionyl chloride; water; hydrogen; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 20 h / 0 - 20 °C
1.2: 18 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 64 h / 20 °C / 2585.81 Torr / Inert atmosphere
With
thionyl chloride; hydrogen; N,N-dimethyl-formamide;
palladium 10% on activated carbon;
In
ethanol; dichloromethane; water;