4-ISOBUTYLSTYRENE

Base Information

• Chemical Name: 4-ISOBUTYLSTYRENE
• CAS No.: 63444-56-4
• Molecular Formula: C12H16
• Molecular Weight: 160.259
• Hs Code.: 2902909090
• Mol file: 63444-56-4.mol

Synonyms:4-Isobutylstyrene;1-ethenyl-4-(2-methylpropyl)benzene;

Chemical Property of 4-ISOBUTYLSTYRENE

Chemical Property:

• Melting Point: -36.9°C (estimate)
• Refractive Index: 1.5218
• Boiling Point: 227oC
• Flash Point: 85oC
• PSA: 0.00000
• Density: 0.882
• LogP: 3.52810

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: p-Isobutylstyrene is a phototransformation product of Ibuprofen (I140000) and Ketoprofen (K200800) in aqueous solutions. p-Isobutylstyrene is also used in the preparation of copolymer series for migration imaging applications.

Technology Process of 4-ISOBUTYLSTYRENE

There total 19 articles about 4-ISOBUTYLSTYRENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ p-isobutylstyrene (63444-56-4)

Guidance literature:

With 2,4,6-trimethyl-pyridine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium dichloride; CyJohnPhos; In N,N-dimethyl acetamide; at 20 ℃; for 15h; Schlenk technique; Inert atmosphere; Irradiation;

Reference yield: 92.0%

1-(4-Isobutylphenyl)ethylisocyanid (132980-23-5) → p-isobutylstyrene (63444-56-4) + 2-(4-isobutylphenyl)propanenitrile (58609-73-7)

Guidance literature:

at 575 - 600 ℃; under 0.0002 - 0.0008 Torr;

Reference yield: 84.0%

4-(2-methyl-1-propyl)benzaldehyde (40150-98-9) + Methyltriphenylphosphonium bromide (1779-49-3) → p-isobutylstyrene (63444-56-4)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; for 16h; Reflux;

DOI:10.1021/ja3045053

upstream raw materials:

1-bromo-4-ethenyl-benzene

2-methylpropylmagnesium chloride

1-(4-isobutylphenyl)ethanol

S-(-)-1-(-)-[4-isobutylphenyl]-chloroethane

Downstream raw materials:

(+/-)-ibuprofen methyl ester

ibuprofen

3-(4'-isobutylphenyl)propionic acid

(2R)-2-<4-(2-Methylpropyl)phenyl>propanal

Refernces

• 1、 Hahm, Hyungwoo,Han, Min Su,Hong, Sukwon,Kim, Jiyun,Ryoo, Jeong Yup. "Photocatalytic carbocarboxylation of styrenes with CO2for the synthesis of γ-aminobutyric esters". . p. 6301 - 6312. Retrieved 2021/07/28.
• 2、 Dong, Xiao-Yang,Cheng, Jiang-Tao,Zhang, Yu-Feng,Li, Zhong-Liang,Zhan, Tian-Ya,Chen, Ji-Jun,Wang, Fu-Li,Yang, Ning-Yuan,Ye, Liu,Gu, Qiang-Shuai,Liu, Xin-Yuan. "Copper-Catalyzed Asymmetric Radical 1,2-Carboalkynylation of Alkenes with Alkyl Halides and Terminal Alkynes". supporting information. p. 9501 - 9509. Retrieved 2020/05/18.