132980-23-5

Basic information

• Product Name: 1-(4-Isobutylphenyl)ethylisocyanid
• Synonyms: 1-(4-Isobutylphenyl)ethylisocyanid
• CAS NO: 132980-23-5
• Molecular Weight: 187.285
• Mol File: 132980-23-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-Isobutylphenyl)ethylisocyanid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Isobutylphenyl)ethylisocyanid(132980-23-5)
• EPA Substance Registry System: 1-(4-Isobutylphenyl)ethylisocyanid(132980-23-5)

Safety Data

• Hazardous Substances Data: 132980-23-5(Hazardous Substances Data)

Upstream product

• 132980-22-4 N-<1-(4-Isobutylphenyl)ethyl>formamid 
• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 

Downstream Products

• 15687-27-1 ibuprofen 
• 63444-56-4 p-isobutylstyrene 
• 58609-73-7 2-(4-isobutylphenyl)propanenitrile 

Relevant articles and documents

New Syntheses of Ibuprofen and Naproxen

A new route for the synthesis of α-arylpropionic acids, in particular for the two most important non-steroidal antiinflammatory compounds Ibuprofen (5) as well as racemic and optically active Naproxen (12), has been developed.N-(1-Arylethyl)formamides 2, 9 are dehydrated to the corresponding isocyanides 3, 10, and these are rearranged by flash pyrolysis to α-arylpropionitriles 4, 11 which are converted into α-arylpropionic acids 5, 12 by hydrolysis under standard conditions.The intermediate 1-(6-methoxy-2-naphthyl)-ethylamine is resolved via its tartrate or mandelic salts. Key Words : Isocyanide - cyanide rearrangement / Ibuprofen / Naproxen / Optically active 1-arylethylamines