6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde

Base Information

• Chemical Name: 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde
• CAS No.: 23576-84-3
• Molecular Formula: C6H3 Cl N2 O S
• Molecular Weight: 186.622
• Hs Code.: 2934100090
• European Community (EC) Number: 673-078-2
• NSC Number: 315209
• DSSTox Substance ID: DTXSID70317394
• Nikkaji Number: J486.533B
• Wikidata: Q72452138
• Mol file: 23576-84-3.mol

Synonyms:23576-84-3;6-chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde;6-chloroimidazo[2,1-b]thiazole-5-carbaldehyde;6-Chloroimidazo[2,1-b]thiazole-5-carboxaldehyde;MFCD00139155;NSC 315209;6-chloroimidazo(2,1-b)thiazole-5-carbaldehyde;NSC315209;SCHEMBL859221;DTXSID70317394;BBL010842;STK801773;AKOS000121663;AT35320;NSC-315209;BP-12387;CS-0205902;FT-0621071;EN300-00980;8D-062;6-chloro-imidazo[2,1-b]thiazole-5-carbaldehyde;A816777;J-015153;J-518618;Z56792049;F3095-4776;6-chloroimidazo[2,1-b]thiazole-5-carboxaldehyde, AldrichCPR

Chemical Property of 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde

Chemical Property:

• Melting Point: 141-142
• Boiling Point: °Cat760mmHg
• PKA: 1.11±0.40(Predicted)
• Flash Point: °C
• PSA: 62.61000
• Density: 1.71g/cm³
• LogP: 1.86170
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 185.9654616
• Heavy Atom Count: 11
• Complexity: 180

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC2=NC(=C(N21)C=O)Cl

Technology Process of 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde

There total 2 articles about 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloroimidazo[2,1-b]thiazole (23576-81-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-chloro-imidazo-[2,1-b]thiazole-5-carbaldehyde (23576-84-3)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; In chloroform; at 0 - 5 ℃;

6-chloroimidazo[2,1-b]thiazole; With piperidine; In chloroform; for 5h; Reflux;

DOI:10.2174/1573406413666171010110819

Reference yield:

→ 6-chloro-imidazo-[2,1-b]thiazole-5-carbaldehyde (23576-84-3)

Guidance literature:

Reference yield: 90.0%

(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (1232223-60-7) + 6-chloro-imidazo-[2,1-b]thiazole-5-carbaldehyde (23576-84-3) → N-(6-chloro-imidazo[2,1-b]thiazole-5-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine (1232221-60-1)

Guidance literature:

In ethanol; at 1 - 30 ℃; for 1h;

upstream raw materials:

6-chloroimidazo[2,1-b]thiazole

N,N-dimethyl-formamide

Downstream raw materials:

5-hydroxymethyl-6-chloroimidazo<2,1-b>thiazole

6-chloro-imidazo[2,1-b]thiazole-5-carboxylic acid

N-(6-chloro-imidazo[2,1-b]thiazole-5-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine

6-Chlorimidazo<2,1-b>thiazol-5-aldoxim

Refernces