Bicyclo[4.1.0]heptan-2-ol

Base Information

• Chemical Name: Bicyclo[4.1.0]heptan-2-ol
• CAS No.: 6376-96-1
• Molecular Formula: C7H12O
• Molecular Weight: 112.172
• Mol file: 6376-96-1.mol

Synonyms:

Chemical Property of Bicyclo[4.1.0]heptan-2-ol

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bicyclo[4.1.0]heptan-2-ol

There total 12 articles about Bicyclo[4.1.0]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

bicyclo[4.1.0]heptane (286-08-8) → 3-hydroxymethylcyclohexene (103668-33-3,3309-97-5) + Bicyclo<4.1.0>heptan-2-ol (6376-96-1)

Guidance literature:

With wild type P_. oleovorans TF₄-1L monogenase; oxygen; Further Variations:; Reagents; Kinetics;

DOI:10.1021/ja001500v

Reference yield: 61.8%

bicyclo[4.1.0]heptane (286-08-8) → 3-hydroxymethylcyclohexene (103668-33-3,3309-97-5) + endo-2-norcaranol (7432-49-7,6376-96-1,31022-87-4,38263-37-5,38263-38-6,136616-41-6) + exo-Bicyclo<4.1.0>heptan-2-ol (31022-87-4) + bicyclo<4.1.0>heptanol-3 endo

Guidance literature:

With air; 1,4-dihydronicotinamide adenine dinucleotide; Fe₂S₂ ferredoxin from Pseudomonas species NCIB 9816-4; α3β3 oxygenase from Pseudomonas species NCIB 9816-4; reductase from Pseudomonas species NCIB 9816-4; In water; at 23 ℃; for 0.5h; pH=6.9;

DOI:10.1021/ja068188v

Reference yield:

8-oxabicyclo[5.1.0]octane (286-45-3) → Bicyclo<4.1.0>heptan-2-ol (6376-96-1) + cycloheptanone (502-42-1)

Guidance literature:

With n-butyllithium; diisopropylamine; In hexane; pentane; Reflux; Inert atmosphere; Schlenk technique;

DOI:10.2174/1570178615666180215145359

upstream raw materials:

bicyclo[4.1.0]heptane

8-oxabicyclo[5.1.0]octane

diazomethane

Cyclohex-2-enol

Downstream raw materials:

3-chloromethylcyclohexene

4-Chlorocycloheptene

cis,trans-2-methyl-1,3-cyclohexanediol

3-(iodomethyl)-1-cyclohexene

Refernces

• 1、 Cooper, Harriet L. R.,Mishra, Girish,Huang, Xiongyi,Pender-Cudlip, Marilla,Austin, Rachel N.,Shanklin, John,Groves, John T.. "Parallel and competitive pathways for substrate desaturation, hydroxylation, and radical rearrangement by the non-heme diiron hydroxylase AlkB". . p. 20365 - 20375. Retrieved 2013/02/25.
• 2、 Newcomb, Martin,Chandrasena, R. Esala P.,Lansakara-P, Dharmika S. P.,Kim, Hye-Yeong,Lippard, Stephen J.,Beauvais, Laurance G.,Murray, Leslie J.,Izzo, Viviana,Hollenberg, Paul F.,Coon, Minor J.. "Desaturase reactions complicate the use of norcarane as a mechanistic probe. Unraveling the mixture of twenty-plus products formed in enzyme-catalyzed oxidations of norcarane". . p. 1121 - 1127. Retrieved 2007/10/03.