Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester
• CAS No.: 63959-88-6
• Molecular Formula: C8H12F3NO3
• Molecular Weight: 227.183
• Mol file: 63959-88-6.mol

Synonyms:TFA-Gly-OtBu;tert-butyl N-(trifluoroacetyl)glycinate;TFA-Gly-Ot-Bu;tert-butyl 2-(2,2,2-trifluoroacetamido)acetate;N-trifluoroacetyl tert-butyl glycinate;TFAGlyOtBu;

Chemical Property of Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 55.40000
• LogP: 1.39750

Purity/Quality:

99% ^*data from raw suppliers

tert-ButylN-(trifluoroacetyl)glycinate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester

There total 5 articles about Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl trifluoroacetate, (383-63-1) + glycine tert-butyl ester hydrochloride (27532-96-3) → tert-butyl N-(trifluoroacetyl)glycinate (63959-88-6)

Guidance literature:

glycine tert-butyl ester hydrochloride; With triethylamine; In methanol; for 0.0833333h; Inert atmosphere;

ethyl trifluoroacetate,; In methanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201914620

Reference yield: 91.0%

2,2,2-trifluoroacetamide (354-38-1) + Glycine tert-butyl ester (6456-74-2) → tert-butyl N-(trifluoroacetyl)glycinate (63959-88-6)

Guidance literature:

With carbon dioxide; In toluene;

DOI:10.1021/acs.joc.1c02077

Reference yield: 84.0%

trifluoroacetic acid-methyl ester (431-47-0) + Glycine tert-butyl ester (6456-74-2) → tert-butyl N-(trifluoroacetyl)glycinate (63959-88-6)

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.3762/bjoc.7.151

upstream raw materials:

TFA-Gly

isobutene

trifluoroacetic acid-methyl ester

Glycine tert-butyl ester

Refernces

• 1、 -. "SYNTHESIS OF A-AMANITIN AND ITS DERIVATIVES". Page/Page column 36. . Retrieved 2021/01/29.
• 2、 Knittel, Caroline H.,Süssmuth, Roderich D.,Siegert, Mary-Ann J.. "A Convergent Total Synthesis of the Death Cap Toxin α-Amanitin". supporting information. p. 5500 - 5504. Retrieved 2020/02/13.