3,9-Dichloroacridine

Base Information

• Chemical Name: 3,9-Dichloroacridine
• CAS No.: 35547-70-7
• Molecular Formula: C13H7Cl2N
• Molecular Weight: 248.111
• Hs Code.: 2933990090
• Mol file: 35547-70-7.mol

Synonyms:3,9-dichloro-acridine;6,9-dichloroacridine;3,9-Dichlor-acridin;Acridine,3,9-dichloro;

Chemical Property of 3,9-Dichloroacridine

Chemical Property:

• Vapor Pressure: 1.41E-06mmHg at 25°C
• Boiling Point: 410.6°Cat760mmHg
• Flash Point: 234.6°C
• PSA: 12.89000
• Density: 1.419g/cm³
• LogP: 4.69480

Purity/Quality:

99% ^*data from raw suppliers

6,9-Dichloroacridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,9-Dichloroacridine is a di-halogenated derivative of acridine (A190900), a quinoline derivative used as manufacturing dyes and as intermediate for antileishmanial agents. 6,9-Dichloroacridine is a di-halogenated derivative of acridine (A190900), a quinoline derivative used as manufacturing dyes and as intermediate for antileishmanial agents

Technology Process of 3,9-Dichloroacridine

There total 11 articles about 3,9-Dichloroacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-anilino-4-nitrobenzoic acid (49551-01-1) + trichlorophosphate (10025-87-3,12599-09-6,63736-95-8,39380-77-3) → 3,9-dichloroacridine (35547-70-7) + 9-chloro-3-nitroacridine (1744-91-8)

Guidance literature:

DOI:10.1039/jr9360001614

Reference yield:

N-phenyl-4-chloroanthranilic acid (19218-88-3) → 3,9-dichloroacridine (35547-70-7)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/ja01195a600

Reference yield:

N-(3-chlorophenyl)anthranilic acid (13278-36-9) → 3,9-dichloroacridine (35547-70-7)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

3-chloroacridin-9(10H)-one

N-phenyl-4-chloroanthranilic acid

N-(3-chlorophenyl)anthranilic acid

trichlorophosphate

Downstream raw materials:

5-Amino-2-chloroacridin

3-chloro-10-methylacridin-9(10H)-one

3-chloroacridin-9(10H)-one

6-chloroacridine

Refernces

• 1、 Johns, Stephen C.,Crouch, Laurie L.E.,Grieve, Stephen,Maloney, Holly L.,Peczkowski, Gary R.,Jones, Allison E.,Sharp, Duncan,Smith, Robert B.. "A rapid, chromatography-free route to substituted acridine-isoalloxazine conjugates under microwave irradiation". supporting information. p. 3308 - 3311. Retrieved 2014/06/09.
• 2、 -. "Tricyclic heterocyclic derivatives". . . Retrieved 2008/06/13.