5-Iodoresorcinol

Base Information

• Chemical Name: 5-Iodoresorcinol
• CAS No.: 64339-43-1
• Molecular Formula: C6H5IO2
• Molecular Weight: 236.009
• Mol file: 64339-43-1.mol

Synonyms:1,3-Benzenediol, 5-iodo-;5-iodobenzene-1,3-diol;

Chemical Property of 5-Iodoresorcinol

Chemical Property:

• Melting Point: 92.5°C
• Boiling Point: 325.6±12.0 °C(Predicted)
• PKA: 8.60±0.10(Predicted)
• PSA: 40.46000
• Density: 1.9169 (estimate)
• LogP: 1.70240
• Solubility.: Ethyl Acetate, Methanol

Purity/Quality:

99.90% ^*data from raw suppliers

5-Iodoresorcinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Iodoresorcinol

There total 11 articles about 5-Iodoresorcinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-iodo-3,5-dimethoxybenzene (25245-27-6) → 5-iodoresorcinol (64339-43-1)

Guidance literature:

With boron tribromide; In dichloromethane; at -20 - 20 ℃;

DOI:10.1016/0968-0896(96)00060-0

Reference yield:

3,5-dihydroxyphenylamine (20734-67-2) → 5-iodoresorcinol (64339-43-1)

Guidance literature:

3,5-dihydroxyphenylamine; With hydrogenchloride; In water;

With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 0.25h;

With potassium iodide; In water; ethyl acetate; for 7h;

DOI:10.1055/s-0031-1289664

Reference yield:

3.5-dimethoxyaniline (10272-07-8) → 5-iodoresorcinol (64339-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaNO₂; HCl

1.2: KI

2.1: BBr₃

With hydrogenchloride; boron tribromide; sodium nitrite;

DOI:10.1021/jo060727r

upstream raw materials:

3-iodo-5-methoxyphenol

1-iodo-3,5-dimethoxybenzene

3,5-dimethoxy-1-phenylmagnesium chloride

1-bromo-3,5-dimethoxybenzene

Downstream raw materials:

3,5-bis(trifluoromethanesulfonyloxy)iodobenzene

5-[(E)-2-(4-methoxyphenyl)vinyl]benzene-1,3-diol

(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

1-ethynyl-3,5-dihydroxybenzene

Refernces

• 1、 Bloemendal, Victor R. L. J.,Sondag, Daan,Elferink, Hidde,Boltje, Thomas J.,van Hest, Jan. C. M.,Rutjes, Floris P. J. T.. "A Revised Modular Approach to (–)-trans-Δ8-THC and Derivatives Through Late-Stage Suzuki–Miyaura Cross-Coupling Reactions". . p. 2289 - 2296. Retrieved 2019/04/03.
• 2、 Albert, Shine K.,Golla, Murali,Thelu, Hari Veera Prasad,Krishnan, Nithiyanandan,Varghese, Reji. "A pH-Responsive DNAsome from the Self-Assembly of DNA–Phenyleneethynylene Hybrid Amphiphile". supporting information. p. 8348 - 8352. Retrieved 2017/06/28.