o-Anilinophenol

Base Information

• Chemical Name: o-Anilinophenol
• CAS No.: 644-71-3
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Hs Code.: 2922299090
• Mol file: 644-71-3.mol

Synonyms:2-Hydroxydiphenylamine;2-Hydroxyphenylphenylamine;o-Anilinophenol

Chemical Property of o-Anilinophenol

Chemical Property:

• Melting Point: 69.5°C
• Refractive Index: 1.5300 (estimate)
• Boiling Point: 322.08°C at 760 mmHg (Cal.)
• PKA: 9.66±0.30(Predicted)
• Flash Point: 139.193°C (Cal.)
• PSA: 32.26000
• Density: 1.203g/cm3 (Cal.)
• LogP: 3.20880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-Anilinophenol

There total 32 articles about o-Anilinophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

iodobenzene (591-50-4) + 2-amino-phenol (95-55-6) → 2-(phenylamino)phenol (644-71-3)

Guidance literature:

With nickel(II) ferrite; caesium carbonate; In 1,4-dioxane; for 8h; Reflux;

DOI:10.1002/adsc.201300686

Reference yield: 93.0%

6-diazo-2-cyclohexen-1-one (928642-45-9) + aniline (62-53-3) → 2-(phenylamino)phenol (644-71-3)

Guidance literature:

With oxygen; copper diacetate; In 1,4-dioxane; at 80 ℃; for 3h; Solvent; Catalytic behavior; Schlenk technique; Sealed tube;

DOI:10.1002/asia.201402080

Reference yield: 92.0%

iodobenzene (591-50-4) + 2-amino-phenol (95-55-6) → 2-(phenylamino)phenol (644-71-3) + o-(diphenylamino)phenol (25069-88-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; In 1,4-dioxane; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja9081815

upstream raw materials:

N-(2-hydroxy-phenyl)-N-phenyl-benzamide

N-(2-hydroxy-phenyl)-N-phenyl-acetamide

benzene-1,2-diol

aniline

Downstream raw materials:

3-phenylbenzo[d]oxazole-2(3H)-one

N-(2-hydroxy-phenyl)-N-phenyl-acetamide

[2-(2-diethylamino-ethoxy)-phenyl]-phenyl-amine

2-methoxy-N-phenylaniline

Refernces

• 1、 Mukherjee, Aparajita,Basu, Semanti,Bhattacharya, Samaresh. "Copper complexes of 1,4-diazabutadiene ligands: Tuning of metal oxidation state and, application in catalytic C-C and C-N bond formation". . . Retrieved 2019/11/11.
• 2、 He, Yue,Mao, Jincheng,Rong, Guangwei,Yan, Hong,Zhang, Guoqi. "Ligand-Free, Cu- and Fe-Catalyzed Selective Ring-Opening Arylations of Benzoxazoles with Aryl Iodides". . p. 1672 - 1676. Retrieved 2016/06/14.