Tetrazolo[1,5-c]quinazoline, 5-phenyl-

Base Information

• Chemical Name: Tetrazolo[1,5-c]quinazoline, 5-phenyl-
• CAS No.: 6499-41-8
• Molecular Formula: C14H9N5
• Molecular Weight: 247.259
• Mol file: 6499-41-8.mol

Synonyms:

Chemical Property of Tetrazolo[1,5-c]quinazoline, 5-phenyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tetrazolo[1,5-c]quinazoline, 5-phenyl-

There total 12 articles about Tetrazolo[1,5-c]quinazoline, 5-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 5-oxo-2-(2-phenylquinazolin-4-yl)-2,5-dihydroisoxazole-4-carboxylate (100422-74-0) → 5-phenyltetrazolo<1,5-c>quinazoline (6499-41-8)

Guidance literature:

With sodium azide; Aliquat 336; In dichloromethane; at 50 ℃; for 3h;

Reference yield: 73.0%

C14H12N4 (6484-29-3) → 5-phenyltetrazolo<1,5-c>quinazoline (6499-41-8)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 5 ℃; for 12h;

DOI:10.1002/ardp.201200376

Reference yield: 69.0%

4-chloro-2-phenylquinazoline (6484-25-9) → 5-phenyltetrazolo<1,5-c>quinazoline (6499-41-8)

Guidance literature:

With sodium azide; In benzene; for 5h; Heating;

DOI:10.1135/cccc19921559

upstream raw materials:

4-chloro-2-phenylquinazoline

ethyl 5-oxo-2-(2-phenylquinazolin-4-yl)-2,5-dihydroisoxazole-4-carboxylate

anthranilic acid amide

2-phenyl-2,3-dihydro-4(1H)-quinazolinone

Downstream raw materials:

C₁₄H₉N₃

C₁₄H₉N₃

C₁₄H₉N₃

2-phenyl-1H-benzo[d]imidazole-1-carbonitrile

Refernces

• 1、 Jia, Feng-Cheng,Zhou, Zhi-Wen,Xu, Cheng,Cai, Qun,Li, Deng-Kui,Wu, An-Xin. "Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy". supporting information. p. 4236 - 4239. Retrieved 2015/09/15.
• 2、 Caiazza, Daniela,Prager, Rolf H.,Schafer, Karl. "The Chemistry of 5-Oxodihydroisoxazoles. XIV. Synthesis of 2-(1-Aryltetrazol-5-yl)propanoic Acids". . p. 1861 - 1872. Retrieved 2007/10/03.