N-Benzyl-1-Phenylethylamine

Base Information

• Chemical Name: N-Benzyl-1-Phenylethylamine
• CAS No.: 50606-93-4
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Hs Code.: 2922399090
• Mol file: 50606-93-4.mol

Synonyms:Acetophenone,2-(benzylamino)- (7CI);2-(Benzylamino)acetophenone;2-Benzylamino-1-phenylethanone;NSC 170271;

Chemical Property of N-Benzyl-1-Phenylethylamine

Chemical Property:

• Vapor Pressure: 1.56E-05mmHg at 25°C
• Refractive Index: 1.581
• Boiling Point: 365.5 °C at 760 mmHg
• PKA: 6.13±0.20(Predicted)
• Flash Point: 139.4 °C
• PSA: 29.10000
• Density: 1.088 g/cm³
• LogP: 3.05000

Purity/Quality:

99% ^*data from raw suppliers

2-(BENZYLAMINO)-1-PHENYLETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Benzyl-1-Phenylethylamine

There total 6 articles about N-Benzyl-1-Phenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

α-bromoacetophenone (70-11-1) + benzylamine (100-46-9) → α-(N-Benzylamino)acetophenone (50606-93-4)

Guidance literature:

In diethyl ether; at -78 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c3ob42309c

Reference yield: 73.0%

2-azido-1-phenylethan-1-one (1816-88-2) → N-(2-oxo-2-phenylethyl)benzamide (4190-14-1) + N-benzyl-N-(2-oxo-2-phenylethyl)benzamide (35363-31-6) + α-(N-Benzylamino)acetophenone (50606-93-4) + acetophenone (98-86-2)

Guidance literature:

In toluene; at 20 ℃; Further byproducts given; UV-irradiation;

DOI:10.1021/ol0068750

Reference yield:

acetophenone (98-86-2) → α-(N-Benzylamino)acetophenone (50606-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / tetrachloromethane / Inert atmosphere

2: triethylamine / 0 °C

With N-Bromosuccinimide; triethylamine; In tetrachloromethane;

DOI:10.1016/j.bmcl.2011.08.078

upstream raw materials:

1-chloroacetophenone

benzylamine

α-bromoacetophenone

2-azido-1-phenylethan-1-one

Downstream raw materials:

2-benzylamino-1-phenyl-ethanol

2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 4-nitrobenzenesulfonate

2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl 4-cyanobenzenesulfonate

2-(benzyl(tert-butoxycarbonyl)amino)-1-phenylethyl naphthalene-1-sulfonate

Refernces

• 1、 Egorov, Maxim,Delpech, Bernard,Aubert, Genevieve,Cresteil, Thierry,Garcia-Alvarez, Maria Concepcion,Collin, Pascal,Marazano, Christian. "A concise formation of N-substituted 3,4-diarylpyrroles-synthesis and cytotoxic activity". supporting information. p. 1518 - 1524. Retrieved 2014/03/21.
• 2、 Laufer, Stefan A.,Hauser, Dominik R. J.,Liedtke, Andy J.. "Regiospecific and highly flexible synthesis of 1,4,5-trisubstituted 2-sulfanylimidazoles from structurally diverse ethanone precursors". . p. 253 - 266. Retrieved 2008/12/22.