6,7-Dihydro-6-methyl-5H-dibenz(c,e)azepine

Base Information

• Chemical Name: 6,7-Dihydro-6-methyl-5H-dibenz(c,e)azepine
• CAS No.: 35232-96-3
• Molecular Formula: C15H15N
• Molecular Weight: 0
• DSSTox Substance ID: DTXSID50956669
• Nikkaji Number: J40.875A
• Wikidata: Q82936778
• Mol file: 35232-96-3.mol

Synonyms:6,7-Dihydro-6-methyl-5H-dibenz(c,e)azepine;35232-96-3;Ro 2-3176;BRN 0162574;5H-Dibenz(c.e)azepine, 6,7-dihydro-6-methyl-;SCHEMBL1649346;DTXSID50956669;Ro-2-3176;LS-60420;6-methyl-6,7-dihydro-5H-dibenzo[c,e]azepine;5H-Dibenz[c,e]azepine, 6,7-dihydro-6-methyl-;6-methyl-6,7-dihydro-5H-benzo[d][2]benzazepine

Chemical Property of 6,7-Dihydro-6-methyl-5H-dibenz(c,e)azepine

Chemical Property:

• Vapor Pressure: 0.000102mmHg at 25°C
• Boiling Point: 337.9°C at 760 mmHg
• Flash Point: 143.4°C
• PSA: 3.24000
• Density: 1.074g/cm³
• LogP: 3.23690
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 209.120449483
• Heavy Atom Count: 16
• Complexity: 214

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CC2=CC=CC=C2C3=CC=CC=C3C1

Technology Process of 6,7-Dihydro-6-methyl-5H-dibenz(c,e)azepine

There total 10 articles about 6,7-Dihydro-6-methyl-5H-dibenz(c,e)azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-methyl-5H-dibenzo[c,e]azepine-5,7(6H)-dione (100891-94-9) → 6-Methyl-6,7-dihydro-5H-dibenzazepin (35232-96-3)

Guidance literature:

With borane; In tetrahydrofuran; for 3h; Heating;

DOI:10.1080/00397919508011465

Reference yield: 88.0%

Bis-(2-iodo-benzyl)-methyl-amine → 6-Methyl-6,7-dihydro-5H-dibenzazepin (35232-96-3)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; copper(I) thiophene-2-carboxylate; for 15h; Ambient temperature;

DOI:10.1021/jo9700078

Reference yield: 83.0%

2,2'-bis-(bromomethyl)-1,1'-biphenyl (38274-14-5) + methylamine (74-89-5) → 6-Methyl-6,7-dihydro-5H-dibenzazepin (35232-96-3)

Guidance literature:

In water; benzene; at 40 ℃; for 12h;

DOI:10.1016/S0040-4020(00)00783-3

upstream raw materials:

2,2'-bis-(bromomethyl)-1,1'-biphenyl

methylamine

N-methyl-5H-dibenzo[c,e]azepine-5,7(6H)-dione

sarcosine

Refernces

• 1、 Akula,Kabalka. "A facile synthesis of 6-alkyl-6,7-dihydro-5H-dibenz[c,e]azepines: Potent hypolipidemics". . p. 3901 - 3906. Retrieved 1995.
• 2、 Azzena, Ugo,Demartis, Salvatore,Pilo, Luciano,Piras, Elisabetta. "Reductive cleavage of benzannelated cyclic ethers and amines: Synthetic applications". . p. 8375 - 8382. Retrieved 2007/10/03.
• 3、 Zhang, Shijie,Zhang, Dawei,Liebeskind, Lanny S.. "Ambient Temperature, Ullmann-like Reductive Coupling of Aryl, Heteroaryl, and Alkenyl Halides". . p. 2312 - 2313. Retrieved 2007/10/03.