ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE

Base Information

• Chemical Name: ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE
• CAS No.: 65651-80-1
• Molecular Formula: C9H15NO2
• Molecular Weight: 169.224
• Mol file: 65651-80-1.mol

Synonyms:

Chemical Property of ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE

Chemical Property:

• Vapor Pressure: 0.028mmHg at 25°C
• Melting Point: 43-45°C
• Boiling Point: 118°C 1mm
• PKA: 6.09±0.20(Predicted)
• Flash Point: 118°C/1mm
• Density: 1.112±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.3% ^*data from raw suppliers

(E)-Ethyl3-(pyrrolidin-1-yl)acrylate 95% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE

There total 4 articles about ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + propynoic acid ethyl ester (623-47-2) → ethyl (E)-3-(pyrrolidin-1-yl)acrylate (65651-80-1)

Guidance literature:

In toluene; at 20 ℃; for 16h;

DOI:10.1111/cbdd.13003

Reference yield: 96.0%

ethyl 3-oxo-3-(pyrrolidin-1-yl)propanoate (35247-24-6) → ethyl (E)-3-(pyrrolidin-1-yl)acrylate (65651-80-1)

Guidance literature:

With bis(triphenylphosphine)carbonyliridium(I) chloride; 1,1,3,3-Tetramethyldisiloxane; In toluene; at 20 ℃; for 1h; Solvent; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2018.12.024

Reference yield: 94.0%

pyrrolidine (123-75-1) + Ethyl propionate (105-37-3,20741-13-3) → ethyl (E)-3-(pyrrolidin-1-yl)acrylate (65651-80-1)

Guidance literature:

In toluene; at 20 ℃; for 16h;

DOI:10.1021/jm3012239

upstream raw materials:

pyrrolidine

propynoic acid ethyl ester

Ethyl propionate

ethyl 3-oxo-3-(pyrrolidin-1-yl)propanoate

Downstream raw materials:

triethyl benzene-1,3,5-tricarboxylate

ethyl 2-formyl-5-phenyl-4-pentenoate

ethyl 2-formyl-3-phenyl-3-pentenoate

5-(Phenylimino)-4-(1-pyrrolidinyl)-2(5H)-thiophenon

Refernces

• 1、 Chen, Guang,Chen, Xiao Yun,Cheng, Xiaofang,Tang, Yaonan,Yuan, Shuxia,Zhang, Luming,Zhu, Baocheng. "Green H 2 O-Promoted Solvent-Free Synthesis of Enaminocarbonyl Compounds with High Stereoselectivity from Electron-Deficient Terminal Alkynes". supporting information. p. 878 - 882. Retrieved 2020/05/28.
• 2、 -. "PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS". Page/Page column 131. . Retrieved 2019/01/10.