2-(TRIFLUOROMETHYL)BENZOFURANE

Base Information

• Chemical Name: 2-(TRIFLUOROMETHYL)BENZOFURANE
• CAS No.: 65715-20-0
• Molecular Formula: C9H5F3O
• Molecular Weight: 186.13100
• Hs Code.: 2932999099
• Mol file: 65715-20-0.mol

Synonyms:2-(TRIFLUOROMETHYL)BENZOFURANE;2-(Trifluormethyl)-benzofuran;2-(TRIFLUOROMETHYL)BENZOFURAN;Benzofuran,2-(trifluoromethyl);

Chemical Property of 2-(TRIFLUOROMETHYL)BENZOFURANE

Chemical Property:

• PSA: 13.14000
• LogP: 3.45160

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Trifluoromethyl)benzofuran 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(TRIFLUOROMETHYL)BENZOFURANE

There total 25 articles about 2-(TRIFLUOROMETHYL)BENZOFURANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C11H8ClF3O2 (1068151-54-1) → 2-(trifluoromethyl)benzofuran (65715-20-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 27h;

DOI:10.1080/00397910802431099

Reference yield: 84.0%

benzofuran-2-boronic acid (98437-24-2) + sodium 2,2,2-trifluoroacetate (2923-18-4) → 2-(trifluoromethyl)benzofuran (65715-20-0)

Guidance literature:

With potassium fluoride; potassium phosphate; In water; N,N-dimethyl-formamide; at 20 ℃; for 48h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.oprd.9b00225

Reference yield: 81.0%

Chlorodifluoromethane (75-45-6) + 2-iodobenzofuran (69626-75-1) → 2-(trifluoromethyl)benzofuran (65715-20-0)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 120 ℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;

DOI:10.1021/ol503548s

upstream raw materials:

1-benzofurane

bis(trifluoroacetyl)peroxide

3-bromobenzofuran

iodotrifluoromethane

Refernces

• 1、 Bazyar, Zahra,Hosseini-Sarvari, Mona. "Au@ZnO Core-Shell: Scalable Photocatalytic Trifluoromethylation Using CF3CO2Na as an Inexpensive Reagent under Visible Light Irradiation". supporting information. p. 2345 - 2353. Retrieved 2019/10/16.
• 2、 Zhong, Sabilla,Hafner, Andreas,Hussal, Christoph,Nieger, Martin,Br?se, Stefan. "Metal-free radical perfluoroalkylation of (hetero)arenes". . p. 6255 - 6258. Retrieved 2015/02/19.