9-CHLOROCARBONYLACRIDINE

Base Information

• Chemical Name: 9-CHLOROCARBONYLACRIDINE
• CAS No.: 66074-67-7
• Molecular Formula: C14H8ClNO
• Molecular Weight: 241.677
• Hs Code.: 2933990090
• Mol file: 66074-67-7.mol

Synonyms:9-Acridinecarbonyl chloride;9-acridine-carboxylic acid chloride;9-Chloroformylacridine;9-acridinecarboxylic chloride;acridine-9-carboxylic acid chloride;

Chemical Property of 9-CHLOROCARBONYLACRIDINE

Chemical Property:

• Melting Point: 225 °C
• Boiling Point: 419.8±18.0 °C(Predicted)
• PKA: 1.49±0.10(Predicted)
• PSA: 29.96000
• Density: 1.363±0.06 g/cm3(Predicted)
• LogP: 3.76700

Purity/Quality:

98%,99%, ^*data from raw suppliers

9-ACRIDINECARBONYLCHLORIDE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-CHLOROCARBONYLACRIDINE

There total 4 articles about 9-CHLOROCARBONYLACRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acridine-9-carboxylic acid (5336-90-3) → 9-acridinecarbonyl chloride (66074-67-7)

Guidance literature:

With thionyl chloride;

DOI:10.1016/S0040-4039(00)61545-9

Reference yield:

acridine-9-carboxylic acid monohydrate (146340-18-3,206557-00-8,332927-03-4) → 9-acridinecarbonyl chloride (66074-67-7)

Guidance literature:

With thionyl chloride;

Reference yield:

acridin-9-yl-acetic acid amide (409109-11-1) → 9-acridinecarbonyl chloride (66074-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; NaNO₂; H₂SO₄

2: SOCl₂; benzene

With thionyl chloride; sulfuric acid; acetic acid; sodium nitrite; benzene;

upstream raw materials:

acridine-9-carboxylic acid

acridin-9-yl-acetic acid amide

1-acridin-9-yl-2-diazo-ethanone

acridine-9-carboxylic acid monohydrate

Downstream raw materials:

methyl acridine-9-carboxylate

9-(p-methanesulfonamidoanilinocarbonyl)acridine

9-(p-nitroanilinocarbonyl)acridine

2,6-dichlorophenyl acridine-9-carboxylate

Refernces

• 1、 Bahr, Nicolaus,Güller, Rolf,Reymond, Jean-Louis,Lerner, Richard A.. "A nitroxyl synthase catalytic antibody". . p. 3550 - 3555. Retrieved 1996.
• 2、 Shinozuka,Nakashima,Shimizu,Sawai. "Synthesis and characterization of polyamine-based biomimetic catalysts as artificial ribonuclease". . p. 117 - 130. Retrieved 2001.
• 3、 Krauser, Joel A.,Joshi, Aarti L.,Kady, Ismail O.. "Metal complexes of modified cyclen as catalysts for hydrolytic restriction of plasmid DNA". . p. 877 - 884. Retrieved 2010.
• 4、 Shinozuka, Kazuo,Seto, Yoshiaki,Sawai, Hiroaki. "A Novel Multifunctionally Labelled DNA Probe Bearing an Intercalator and a Fluorophore". . p. 1377 - 1378. Retrieved 1994.
• 5、 -. "AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS". Page/Page column 81. . Retrieved 2019/02/06.
• 6、 Díaz-Argelich, Nuria,Encío, Ignacio,Plano, Daniel,Fernandes, Aristi P.,Palop, Juan Antonio,Sanmartín, Carmen. "Novel methylselenoesters as antiproliferative agents". . . Retrieved 2017/08/30.