9-Acridinecarboxylic acid, 2,6-dichlorophenyl ester

Base Information

• Chemical Name: 9-Acridinecarboxylic acid, 2,6-dichlorophenyl ester
• CAS No.: 158749-41-8
• Molecular Formula: C20H11Cl2NO2
• Molecular Weight: 368.219
• Mol file: 158749-41-8.mol

Synonyms:

Chemical Property of 9-Acridinecarboxylic acid, 2,6-dichlorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-Acridinecarboxylic acid, 2,6-dichlorophenyl ester

There total 2 articles about 9-Acridinecarboxylic acid, 2,6-dichlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,6-Dichlorophenol (87-65-0) + 9-acridinecarbonyl chloride (66074-67-7) → 2,6-dichlorophenyl acridine-9-carboxylate (158749-41-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/0040-4039(96)01980-6

Reference yield:

acridine-9-carboxylic acid (5336-90-3) → 2,6-dichlorophenyl acridine-9-carboxylate (158749-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / Heating

With thionyl chloride;

DOI:10.1107/S0108270105004506

Reference yield:

2,6-dichlorophenyl acridine-9-carboxylate (158749-41-8) → 2',6'-dichlorophenyl 10-carboxymethylacridinium-9-carboxylate trifluoromethanesulfonate

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 10 h / Ambient temperature

2: 33percent HBr/AcOH / 0.5 h / 50 °C

With hydrogen bromide; acetic acid; In dichloromethane;

DOI:10.1016/0040-4039(96)01980-6

upstream raw materials:

2,6-Dichlorophenol

9-acridinecarbonyl chloride

acridine-9-carboxylic acid

Refernces

• 1、 Sikorski, Artur,Krzyminski, Karol,Konitz, Antoni,Blazejowski, Jerzy. "9-(2,6-Dichlorophenoxycarbonyl)10-methylacridinium trifluoro- methanesulfonate and its precursor 2,6-dichlorophenyl acridine-9-carboxylate". . p. o227-o230. Retrieved 2005.