2-Propenoic acid, 3-(2,4-dimethoxyphenyl)-, methyl ester, (E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(2,4-dimethoxyphenyl)-, methyl ester, (E)-
• CAS No.: 66417-42-3
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol file: 66417-42-3.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 3-(2,4-dimethoxyphenyl)-, methyl ester, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(2,4-dimethoxyphenyl)-, methyl ester, (E)-

There total 14 articles about 2-Propenoic acid, 3-(2,4-dimethoxyphenyl)-, methyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4 dimethoxybenzoic acid (91-52-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester (66417-42-3)

Guidance literature:

With oxygen; palladium diacetate; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 120 ℃; for 10h; under 760.051 Torr; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/ol102158n

Reference yield: 90.0%

methanol (67-56-1) + (E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid (16909-09-4) → (E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester (66417-42-3)

Guidance literature:

With sulfuric acid; for 12h; Heating;

DOI:10.1021/je00054a042

Reference yield: 32.0%

2,4 dimethoxybenzoic acid (91-52-1) + tert-butyl((1-methoxyprop-1-en-1-yl)oxy)dimethylsilane (89337-61-1) → 3,3-bis(2,4-dimethoxyphenyl)acrylic acid methyl ester (1262097-80-2) + (E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester (66417-42-3)

Guidance literature:

With N,N-diphenylaminobenzene; oxygen; palladium diacetate; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 120 ℃; for 24h; under 760.051 Torr; optical yield given as %de; Molecular sieve;

DOI:10.1039/c0dt01234c

upstream raw materials:

diazomethane

(E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid

7-methoxycoumarin

3-(2,4-dimethoxy-phenyl)-3-methoxy-propionic acid methyl ester

Downstream raw materials:

2,4-dimethoxyphenol

(E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid

methyl-3-(2,4-dimethoxyphenyl)propanoate

2,4-dimethoxyphenyl benzoate

Refernces

• 1、 Fu, Zhengjiang,Huang, Shijun,Kan, Jian,Su, Weiping,Hong, Maochun. "Pd-catalyzed decarboxylative arylation of silyl enol ester sp3 β-C-H bond under aerobic conditions". supporting information; experimental part. p. 11317 - 11321. Retrieved 2011/02/16.
• 2、 Sunnerheim, Kerstin,Nordqvist, Anneli,Nordlander, Goeran,Borg-Karlson, Anna-Karin,Unelius, C. Rickard,Bohman, Bjoern,Nordenhem, Henrik,Hellqvist, Claes,Karlen, Anders. "Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach". . p. 9365 - 9372. Retrieved 2008/03/17.