2,4-Dimethoxyphenol

Base Information

• Chemical Name: 2,4-Dimethoxyphenol
• CAS No.: 13330-65-9
• Molecular Formula: C8H10O3
• Molecular Weight: 154.166
• Hs Code.: 2909500000
• Mol file: 13330-65-9.mol

Synonyms:2,4-Dimethoxyphenol;3-Methoxy-4-hydroxyanisole;

Chemical Property of 2,4-Dimethoxyphenol

Chemical Property:

• Vapor Pressure: 0.00466mmHg at 25°C
• Melting Point: 28 °C
• Refractive Index: 1.522
• Boiling Point: 268.4 °C at 760 mmHg
• PKA: 10.46±0.18(Predicted)
• Flash Point: 116.1 °C
• PSA: 38.69000
• Density: 1.134 g/cm³
• LogP: 1.40940
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2,4-Dimethoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dimethoxyphenol

There total 28 articles about 2,4-Dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-Dimethoxybenzaldehyde (613-45-6) → 2,4-dimethoxyphenol (13330-65-9)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; In methanol; water; at 20 ℃; for 20h;

DOI:10.1002/ejic.201900510

Reference yield: 95.0%

potassium (2,4-dimethoxyphenyl)trifluoroborate → 2,4-dimethoxyphenol (13330-65-9)

Guidance literature:

With Oxone; water; In acetone; at 20 ℃; for 0.0333333h;

DOI:10.1021/jo102208d

Reference yield: 94.0%

1-iodo-2,4-dimethoxybenzene (20469-63-0) → 2,4-dimethoxyphenol (13330-65-9)

Guidance literature:

With water; ethylene glycol; potassium hydroxide; copper dichloride; In dimethyl sulfoxide; at 120 ℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1002/bkcs.10576

upstream raw materials:

2,4-dimethoxyphenyl acetate

2,4-dimethoxyphenyl formate

(E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester

peracetic acid

Downstream raw materials:

2-(2,4-dimethoxy-phenoxy)-4-methoxy-benzoic acid

2-methoxy-1,4-benzoquinone

5-bromo-2,4-dimethoxyphenol

2,4-dimethoxyphenyl acetate

Refernces

• 1、 Boyd, Derek R.,Sharma, Narain D.,Malone, John F.,McIntyre, Peter B. A.,McRoberts, Colin,Floyd, Stewart,Allen, Christopher C. R.,Gohil, Amit,Coles, Simon J.,Horton, Peter N.,Stevenson, Paul J.. "Toluene dioxygenase-catalyzed synthesis and reactions of cis -diol metabolites derived from 2- and 3-methoxyphenols". . p. 3429 - 3439. Retrieved 2015.
• 2、 Abid, Mohammed,Nouch, Ryan,Bradshaw, Tracey D.,Lewis, William,Woodward, Simon. "Tripodal O-N-O Bis-Phenolato Amine Titanium(IV) Complexes Show High in vitro Anti-Cancer Activity". . p. 2774 - 2780. Retrieved 2019.
• 3、 Michel, Fabien,Thomas, Fabrice,Hamman, Sylvain,Saint-Aman, Eric,Bucher, Christophe,Pierre, Jean-Louis. "Galactose oxidase models: Solution chemistry, and phenoxyl radical generation mediated by the copper status". . p. 4115 - 4125. Retrieved 2004.
• 4、 Joseph-Nathan,Dominguez,Ortega. "Shift reagent 1H NMR study of methoxycoumarins". . p. 1141 - 1144. Retrieved 1984.
• 5、 Zhang, Jian,Mu, Keman,Yang, Peng,Feng, Xinqian,Zhang, Di,Fan, Xiangyu,Wang, Qiantao,Mao, Shengjun. "Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives". . . Retrieved 2021/08/03.
• 6、 Zhu, Runqing,Sun, Qianqian,Li, Jing,Li, Luohao,Gao, Qinghe,Wang, Yakun,Fang, Lizhen. "Para -Selective hydroxylation of alkyl aryl ethers". supporting information. p. 13190 - 13193. Retrieved 2021/12/16.