4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER
• CAS No.: 6274-54-0
• Molecular Formula: C10H12 O4 S
• Molecular Weight: 228.269
• Hs Code.: 2916399090
• Mol file: 6274-54-0.mol

Synonyms:Benzoicacid, p-(methylsulfonyl)-, ethyl ester (6CI,8CI); Ethyl4-methylsulfonylbenzoate; NSC 37493

Chemical Property of 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.35E-06mmHg at 25°C
• Boiling Point: 387.2°C at 760 mmHg
• Flash Point: 188°C
• PSA: 68.82000
• Density: 1.229g/cm³
• LogP: 2.34760

Purity/Quality:

99%min ^*data from raw suppliers

4-Methanesulfonyl-benzoicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER

There total 7 articles about 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + ethanol (64-17-5) + 4-(methylsulfonyl)phenyl 2,3,4,5,6-pentafluorobenzenesulfonate → methylsulfonyl-4 benzoate d'ethyle (6274-54-0)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; at 20 ℃; for 16h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201600736

Reference yield: 84.0%

ethanol (64-17-5) + 4-methylsulfonylbenzoyl chloride (40913-92-6) → methylsulfonyl-4 benzoate d'ethyle (6274-54-0)

Guidance literature:

With pyridine; for 3h;

Reference yield: 82.0%

→ methylsulfonyl-4 benzoate d'ethyle (6274-54-0)

Guidance literature:

upstream raw materials:

ethanol

4-methylsulfonylbenzoyl chloride

4-methylsulfonylbenzoic acid

4-methanesulfonyl-phenol

Downstream raw materials:

1-(4-methanesulfonyl-phenyl)-2-pyridin-4-yl-ethanone

4-(ethoxycarbonyl)-benzenesulfinic acid

1-(chloromethyl)-4-(methylsulfonyl)benzene

(E)-1,2-bis(4-(methylsulfonyl)phenyl)ethene

Refernces

• 1、 Joseph, Jayan T.,Sajith, Ayyiliath M.,Ningegowda, Revanna C.,Shashikanth, Sheena. "Room Temperature Carbonylation of (Hetero) Aryl Pentafluorobenzenesulfonates and Triflates using Palladium-Cobalt Bimetallic Catalyst: Dual Role of Cobalt Carbonyl". . p. 419 - 425. Retrieved 2017/02/10.
• 2、 Saidugari, Swamy,Vadali, Lakshmana Rao,Vidya,Ram. "Synthesis, characterization and antimicrobial evaluation of novel (E)-N′-(4-(1-((3,4-dimethoxypyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)benzylidene)benzohydrazide derivatives". . p. 2155 - 2161. Retrieved 2016/10/24.