40913-92-6

Basic information

• Product Name: 4-(Methylsulfonyl)benzoyl chloride
• Synonyms: 4-(Methylsulfonyl)benzoyl chloride;Benzoyl chloride, 4-(methylsulfonyl)-
• CAS NO: 40913-92-6
• Molecular Formula: C₈H₇ClO₃S
• Molecular Weight: 218.65738
• Mol File: 40913-92-6.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(Methylsulfonyl)benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Methylsulfonyl)benzoyl chloride(40913-92-6)
• EPA Substance Registry System: 4-(Methylsulfonyl)benzoyl chloride(40913-92-6)

Safety Data

• Hazardous Substances Data: 40913-92-6(Hazardous Substances Data)

Upstream product

• 4052-30-6 4-methylsulfonylbenzoic acid 
• 79-37-8 oxalyl dichloride 
• 68-12-2 N,N-dimethyl-formamide 
• 623-13-2 4-methylphenyl methylsulfide 
• 104-96-1 4-methylsulfanylaniline 
• 21382-98-9 p-cyanophenyl methyl sulfide 
• 3185-99-7 Methyl p-tolyl sulfone 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 710-24-7 4-acetamidobenzenesulfinic acid 
• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 5470-49-5 4-methanesulfonylphenylamine 
• 22821-80-3 N-(4-methanesulfonylphenyl)acetamide 

Downstream Products

• 102160-77-0 4-methanesulfonyl-benzoic acid-[5-(4-nitro-phenoxy)-pentylamide] 
• 22821-70-1 methyl 4-(methanesulfonyl)benzoate 
• 53090-47-4 3-(4-methanesulfonyl-phenyl)-3-oxo-propionic acid ethyl ester 
• 10297-73-1 4-(methanesulfonyl)acetophenone 
• 4461-38-5 4-(methylsulfonyl)benzamide 
• 35674-93-2 4-methylsulfonylbenzoyl azide 
• 53554-94-2 4-methylsulfonylbenzoic acid hydrazide 
• 72593-31-8 N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-4-methanesulfonyl-benzamide 
• 329776-71-8 Phenyl 4-(methylsulfonyl)benzoate 
• 500870-77-9 2-N-(4-methylsulfonylbenzoyl)-amide-4'-chloro-benzophenone 
• 500870-85-9 N-[2-(4-methoxybenzoyl)phenyl]-4-(methylsulfonyl)benzamide 
• 500870-81-5 2-N-(4-methylsulfonylbenzoyl)-amide-4'-methyl-benzophenone 
• 674802-92-7 2-N-(4-methylsulfonylbenzoyl)-amide-5-chloro-4'-chloro-benzophenone 

Relevant articles and documents

Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors

We identified nitazoxanide (NTZ) as a moderate STAT3 pathway inhibitor through immunoblot analysis and a cell-based IL-6/JAK/STAT3 pathway activation assay. A series of thiazolide derivatives were designed and synthesized to further validate the thiazolide scaffold as STAT3 inhibitors. Eight out of 25 derivatives displayed potencies greater than that of NTZ, and their STAT3 pathway inhibitory activities were found to be significantly correlated with their antiproliferative activities in HeLa cells. Derivatives 15 and 24 were observed to be more potent than the positive control WP1066, which is under phase I clinical trials. Compared with NTZ, 15 also exhibited much improved in vivo pharmacokinetic parameters in rats and efficacies against proliferations in multiple cancer cell lines, indicating a broad-spectrum effect of these thiazolides as antitumor agents targeted on STAT3.

Lappaconitine derivative with analgesic activity, and preparation method and application thereof

The invention provides a lappaconitine derivative with analgesic activity, and a preparation method and application thereof. The structure of the lappaconitine derivative is as shown in formula I in the specification. The lappaconitine derivative provided by the invention is high in analgesic activity, good in water solubility and low in biotoxicity, can be used for preparing low-toxicity analgesic drugs, and is wide in application prospect.

Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors

A series of anthranilamide derivatives were designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound 12a displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50 = 0.48 μM) than LY2940680 (IC50 = 0.79 μM).