1-(Azidomethyl)-4-methoxybenzene

Base Information

• Chemical Name: 1-(Azidomethyl)-4-methoxybenzene
• CAS No.: 70978-37-9
• Molecular Formula: C8H9N3O
• Molecular Weight: 163.179
• Hs Code.: 2929909090
• DSSTox Substance ID: DTXSID60448727
• Nikkaji Number: J258.334H
• Wikidata: Q72444603
• ChEMBL ID: CHEMBL3236139
• Mol file: 70978-37-9.mol

Synonyms:1-(azidomethyl)-4-methoxybenzene;70978-37-9;4-Methoxybenzyl azide;Benzene, 1-(azidomethyl)-4-methoxy-;MFCD11637170;4-(Azidomethyl)anisole;p-anisyl azide;4-methoxybenzylazide;p-Methoxybenzyl azide;para-methoxy benzyl azide;1-azidomethyl-4-methoxy-benzene;CHEMBL3236139;SCHEMBL13547438;DTXSID60448727;IAKGGJYLHBHSQD-UHFFFAOYSA-N;VCA97837;AKOS009452352;BS-13672;SY184504;EN300-66144;D87636;A898160;F2157-0496

Chemical Property of 1-(Azidomethyl)-4-methoxybenzene

Chemical Property:

• Melting Point: 70-71℃
• Refractive Index: 1.5272 (589.3 nm 20℃)
• Boiling Point: 126 °C(Press: 14 Torr)
• PSA: 58.98000
• Density: 1.063 g/cm3 (420 oC)
• LogP: 1.95826
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 163.074561919
• Heavy Atom Count: 12
• Complexity: 169

Purity/Quality:

98%Min ^*data from raw suppliers

1-(azidomethyl)-4-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CN=[N+]=[N-]

Technology Process of 1-(Azidomethyl)-4-methoxybenzene

There total 23 articles about 1-(Azidomethyl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-methoxybenzyl chloride (824-94-2) → 1-(azidomethyl)-4-methoxybenzene (70978-37-9)

Guidance literature:

With sodium azide; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/jm5001453

Reference yield: 100.0%

p-Methoxybenzyl bromide (2746-25-0) → 1-(azidomethyl)-4-methoxybenzene (70978-37-9)

Guidance literature:

With sodium azide; In tetrahydrofuran; water; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1055/s-0034-1379887

Reference yield: 100.0%

4-Methoxybenzyl alcohol (105-13-5) → 1-(azidomethyl)-4-methoxybenzene (70978-37-9)

Guidance literature:

With thionyl chloride; sodium azide; In N,N-dimethyl-formamide;

DOI:10.1055/s-0030-1260943

upstream raw materials:

p-methoxybenzyl chloride

trimethylsilylazide

p-Methoxybenzyl bromide

(4-methoxybenzyl)-3'-cyanopyridinium chloride

Downstream raw materials:

ethyl 1-(4-methoxybenzyl)-1H-tetrazole-5-carboxylate

4,9-dihydro-4,9-dioxo-1-(4-methoxybenzyl)naphtho<2,3-d>-v-triazole

1-(4-methoxybenzyl)-4-phenyl-1H-1,2,3-triazole

N-(4-methoxyphenylmethyl)carbamic acid ethyl ester

Refernces

• 1、 Bai, Chunmei,Bian, Ming,Du, Huan-Huan,Gong, Guohua,Liu, Chunyan,Ma, Qianqian,Quan, Zhe-Shan,Wei, Chengxi. "Synthesis and Evaluation of Bakuchiol Derivatives as Potent Anti-inflammatory Agents in Vitro and in Vivo". supporting information. p. 15 - 24. Retrieved 2022/01/27.
• 2、 -. "COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES". Paragraph 0508; 0522. . Retrieved 2021/02/26.