MethylaMido Cyclopropanoate

Base Information

• Chemical Name: MethylaMido Cyclopropanoate
• CAS No.: 7108-40-9
• Molecular Formula: C5H9NO
• Molecular Weight: 99.1326
• Hs Code.: 2924299090
• Mol file: 7108-40-9.mol

Synonyms:N-methyl cyclopropanecarboxamide;N-Methyl-cyclopropancarboxamid;N-Methylcyclopropylcarboxamide;Cyclopropanecarboxamide,N-methyl;N-Methyl-cyclopropancarbamid;

Chemical Property of MethylaMido Cyclopropanoate

Chemical Property:

• PSA: 32.59000
• LogP: 0.98270

Purity/Quality:

95% ^*data from raw suppliers

N-Methylcyclopropanecarboxamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MethylaMido Cyclopropanoate

There total 2 articles about MethylaMido Cyclopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C14H16O4 + methylamine (74-89-5) → Mesitol (527-60-6) + N-methylcyclopropane carboxamide (7108-40-9) + 1-(METHYLCARBAMOYL)CYCLOPROPANE-1-CARBOXYLIC ACID

Guidance literature:

In ethanol; at 25 ℃; for 1h;

DOI:10.1021/acs.orglett.5b00953

Reference yield:

rel-(1S,2R)-2-(acetoxy)-1-cyclohexyl-2-phenylethyl cyclopropanecarboxylate + methylamine (74-89-5) → N-methyl-acetamide (79-16-3) + N-methylcyclopropane carboxamide (7108-40-9) + (±)-(1R,2S)-1-phenyl-2-cyclohexylethane-1,2-diol

Guidance literature:

DOI:10.1021/acs.orglett.5b02674

Reference yield: 84.0%

N-methylcyclopropane carboxamide (7108-40-9) + o-azidobenzoyl chloride (34897-85-3) → Cyclopropanecarboxylic acid (2-azido-benzoyl)-methyl-amide

Guidance literature:

With triethylamine; In benzene; at 80 ℃; for 2h;

DOI:10.1016/S0040-4020(01)89515-6

upstream raw materials:

methylamine

Downstream raw materials:

cyclopropylmethyl(methyl)amine

Refernces

• 1、 Alamillo-Ferrer, Carla,Davidson, Stuart C.,Rawling, Michael J.,Theodoulou, Natalie H.,Campbell, Matthew,Humphreys, Philip G.,Kennedy, Alan R.,Tomkinson, Nicholas C. O.. "Alkene anti-Dihydroxylation with Malonoyl Peroxides". supporting information. p. 5132 - 5135. Retrieved 2015/11/03.