Benzenemethanol, 2-amino-5-bromo-a-phenyl-

Base Information

• Chemical Name: Benzenemethanol, 2-amino-5-bromo-a-phenyl-
• CAS No.: 7141-05-1
• Molecular Formula: C13H12BrNO
• Molecular Weight: 278.148
• Mol file: 7141-05-1.mol

Synonyms:2-Amino-5-brom-benzhydrol;2-amino-5-bromo-benzhydrol;5-Brom-2-amino-benzhydrol;

Chemical Property of Benzenemethanol, 2-amino-5-bromo-a-phenyl-

Chemical Property:

• PSA: 46.25000
• LogP: 3.69420

Purity/Quality:

95% ^*data from raw suppliers

(2-Amino-5-bromophenyl)(phenyl)methanol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 2-amino-5-bromo-a-phenyl-

There total 11 articles about Benzenemethanol, 2-amino-5-bromo-a-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-amino-5-bromobenzophenone (39859-36-4) → (2-amino-5-bromophenyl)phenylmethanol (7141-05-1)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃;

Reference yield:

(2-aminophenyl)(phenyl)methanone (2835-77-0) → (2-amino-5-bromophenyl)phenylmethanol (7141-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform; bromine

2: sodium-amalgam; aqueous ethanol

With sodium amalgam; ethanol; chloroform; bromine;

DOI:10.1002/hlca.19410240191

Reference yield:

phenyllithium (591-51-5) + 5-Bromo-2-aminobenzoic acid (5794-88-7) → (2-amino-5-bromophenyl)phenylmethanol (7141-05-1)

Guidance literature:

In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2008.08.015

upstream raw materials:

(2-amino-3,5-dibromophenyl)phenylmethanone

ethanol

2-nitrobenzophenone

2-Acetylamino-3,5-dibromobenzophenone

Downstream raw materials:

2-(N-carbobenzoxyglycyl-glycyl)amido-5-bromobenzhydrol

(2-amino-5-bromophenyl)diphenylmethanol

6-bromo-2,4-diphenylquinazoline

6-bromo-4-phenylquinazoline

Refernces

• 1、 -. "DIHYDROQUINAZOLINONE ANALOGUES". . . Retrieved 2014/10/16.
• 2、 Kern, Jeffrey C.,Terefenko, Eugene A.,Fensome, Andrew,Unwalla, Ray,Wrobel, Jay,Cohen, Jeffrey,Zhu, Yuan,Berrodin, Thomas J.,Yudt, Matthew R.,Winneker, Richard C.,Zhang, Zhiming,Zhang, Puwen. "1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5′-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators". scheme or table. p. 5015 - 5017. Retrieved 2009/05/30.