4-(o-Tolyl)morpholine

Base Information

• Chemical Name: 4-(o-Tolyl)morpholine
• CAS No.: 7178-40-7
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID60431139
• Nikkaji Number: J1.188.297H
• Wikidata: Q82244950
• Mol file: 7178-40-7.mol

Synonyms:4-(o-Tolyl)morpholine;7178-40-7;4-(2-methylphenyl)morpholine;4-o-tolylmorpholine;N-(2-methylphenyl)morpholine;SCHEMBL1450530;DTXSID60431139;BOAGUMGJQAXAEN-UHFFFAOYSA-N;J-515897

Chemical Property of 4-(o-Tolyl)morpholine

Chemical Property:

• PSA: 12.47000
• LogP: 1.89660
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

98%min ^*data from raw suppliers

4-(o-Tolyl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1N2CCOCC2

Technology Process of 4-(o-Tolyl)morpholine

There total 27 articles about 4-(o-Tolyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 2-methylphenyl bromide (95-46-5) → N-(o-tolyl)morpholine (7178-40-7)

Guidance literature:

With (SIPr)Pd(methallyl)Cl; lithium hexamethyldisilazane; In tetrahydrofuran; at 22 ℃; for 0.0166667h; Inert atmosphere;

DOI:10.1039/b801479e

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 2-methylchlorobenzene (95-49-8) → N-(o-tolyl)morpholine (7178-40-7)

Guidance literature:

With potassium tert-butylate; In 1,4-dioxane; at 110 ℃; for 3h;

DOI:10.1016/j.jorganchem.2007.05.022

Reference yield: 98.0%

4-(benzoyloxy)morpholine (5765-65-1) + tri-o-tolylboroxine (7294-50-0) → N-(o-tolyl)morpholine (7178-40-7)

Guidance literature:

tri-o-tolylboroxine; With potassium carbonate; In 1,4-dioxane; at 130 ℃; for 24h; Inert atmosphere;

4-(benzoyloxy)morpholine; In 1,4-dioxane; Inert atmosphere;

DOI:10.1021/ol301912a

upstream raw materials:

o-toluidine

diethylene glycol

morpholine

2-methylphenyl bromide

Downstream raw materials:

4-(2-methyl-cyclohexa-1,3-dienyl)-morpholine

2-(N-o-tolylformamido)ethyl formate

Refernces

• 1、 Akiyama, Toshiki,Arai, Masayoshi,Arisawa, Mitsuhiro,Haneoka, Hitoshi,Harada, Kazuo,Murai, Kenichi,Murakami, Yosuke,Ohki, Yuuta,Ohta, Ryousuke,Sako, Makoto,Sirimangkalakitti, Natchanun,Suzuki, Takeyuki,Takahashi, Naoyuki,Takehara, Tsunayoshi,Yamada, Makito. "Product selective reaction controlled by the combination of palladium nanoparticles, continuous microwave irradiation, and a co-existing solid; ligand-free Buchwald-Hartwig aminationvs.aryne amination". supporting information. p. 8131 - 8137. Retrieved 2021/10/29.
• 2、 Duan, Wentao,Lian, Qi,Wang, Songping,Wei, Wentao,Zhou, Jingwei. "Catalyst-free photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines". supporting information. p. 3261 - 3267. Retrieved 2021/05/21.