5765-65-1

Basic information

• Product Name: BENZOIC ACID MORPHOLIN-4-YL ESTER
• Synonyms: BENZOIC ACID MORPHOLIN-4-YL ESTER
• CAS NO: 5765-65-1
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.22582
• Mol File: 5765-65-1.mol
• Article Data: 45

Chemical Properties

• Melting Point: 83 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 314.3±52.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• PKA: -2.50±0.20(Predicted)
• CAS DataBase Reference: BENZOIC ACID MORPHOLIN-4-YL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOIC ACID MORPHOLIN-4-YL ESTER(5765-65-1)
• EPA Substance Registry System: BENZOIC ACID MORPHOLIN-4-YL ESTER(5765-65-1)

Safety Data

• Hazardous Substances Data: 5765-65-1(Hazardous Substances Data)

Usage

Uses

Benzoic acid morpholin-4-yl ester is a useful research chemical.

Upstream product

• 110-91-8 morpholine 
• 94-36-0 dibenzoyl peroxide 
• 98-88-4 benzoyl chloride 
• 5765-63-9 4-hydroxymorpholine 
• 65-85-0 benzoic acid 

Downstream Products

• 92-53-5 4-Phenylmorpholine 
• 7178-40-7 N-(o-tolyl)morpholine 
• 10316-00-4 4-benzyl-morpholine 
• 27347-14-4 N-(4-methoxyphenyl)morpholine 
• 13063-60-0 N-1-octyl morpholine 
• 30483-75-1 4-bromophenyl-morpholine 
• 87350-77-4 N-(4-iodophenyl)morpholine 
• 113845-69-5 4-(4-trifluoromethylphenyl)morpholine 
• 132993-25-0 trifluoromethanesulfonic acid 4-(morpholin-4-yl)phenyl ester 
• 19614-15-4 4-(morpholin-4-yl)benzoic acid ethyl ester 
• 189065-49-4 4-(3-(trifluoromethyl)phenyl)morpholine 
• 5320-98-9 N-(2-nitrophenyl)morpholine 
• 10282-31-2 4-morpholinobenzonitrile 
• 98223-72-4 N-(1-naphthyl)morpholine 

Relevant articles and documents

Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration

We describe a new strategy for aminoarylation of alkenes by copper-catalyzed smiles rearrangement using O-benzoylhydroxylamines as the amine reagent. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition.

Palladium-Catalyzed C-H Amination/[2 + 3] or [2 + 4] Cyclization via C(sp3or sp2)-H Activation

This report describes a palladium-catalyzed Catellani reaction consisting of amination/[2 + 3] or [2 + 4] cyclization via a carboxylate ligand-exchange strategy. This method effectively activates ortho-substituents that avoid a second C-H palladation. The scope of substrates was broad, o-methyl-substituted iodoarenes were applied to the reaction smoothly, and o-phenyl-substituted iodoarenes can also be obtained by this method. In terms of mechanism, density functional theory calculations proved the sequence of the key five-membered aryl-norbornene-palladacycle intermediate formation and C(sp3 or sp2)-H activation.

A carboxylate-assisted amination/unactivated C(sp2)-H arylation reactionviaa palladium/norbornene cooperative catalysis

This report describes a carboxylate-assisted palladium-catalysed Catellani reaction, which is compatible withortho-amination and unactivated C(sp2)-H arylation. This method was used to synthesize a series of 1-amino substituted dihydrophenanthridines, phenanthridines and 6H-benzo[c]chromenes. Based on kinetic isotope experiments, the kinetic curve proves that pivalic acid accelerates the reaction rate of unactivated C(sp2)-H activation, and thus this rate can keep up with the five membered aryl-norbornene-palladacycle (ANP) intermediate.