87350-77-4

Basic information

• Product Name: 4-(4-IODOPHENYL)MORPHOLINE
• Synonyms: 4-(4-IODOPHENYL)MORPHOLINE;1-Iodo-4-(morpholin-4-yl)benzene;4-Iodomorpholinobenzene;4-(4-Iodophenyl)morpholine 97%;Morpholine,4-(4-iodophenyl)-
• CAS NO: 87350-77-4
• Molecular Formula: C₁₀H₁₂INO
• Molecular Weight: 289.11
• Product Categories: pharmacetical;Halides;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 87350-77-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 146℃
• Boiling Point: 358.6 °C at 760 mmHg
• Flash Point: 170.7 °C
• Appearance: /
• Density: 1.653 g/cm³
• Vapor Pressure: 2.53E-05mmHg at 25°C
• Refractive Index: 1.614
• PKA: 4.22±0.40(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-(4-IODOPHENYL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-IODOPHENYL)MORPHOLINE(87350-77-4)
• EPA Substance Registry System: 4-(4-IODOPHENYL)MORPHOLINE(87350-77-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-52/53
• Safety Statements: 61
• WGK Germany: 3
• Hazardous Substances Data: 87350-77-4(Hazardous Substances Data)

Usage

General Description

4-(4-Iodophenyl)morpholine is a chemical compound that belongs to the class of organic compounds known as morpholines. It is a heterocyclic compound containing a morpholine ring and an iodophenyl group. 4-(4-IODOPHENYL)MORPHOLINE is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active molecules. It has also been studied for its potential use in the treatment of cancer and other diseases. Additionally, 4-(4-Iodophenyl)morpholine has been investigated for its antimicrobial and antifungal properties, making it a versatile and valuable chemical in both the pharmaceutical and agricultural industries.

InChI:InChI=1/C10H12INO/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8H2

Upstream product

• 92-53-5 4-Phenylmorpholine 
• 110-91-8 morpholine 
• 109586-39-2 4-iodophenyl trifluoromethanesulfonate 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 5572-94-1 5,5-dimethyl-2-(4-iodophenyl)-1,3,2-dioxaborinane 
• 5122-99-6 4-iodophenylboronic acid 
• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 82113-65-3 bis(trifluoromethanesulfonyl)amide 
• 37828-58-3 lithium morpholide 
• 624-38-4 para-diiodobenzene 
• 591-50-4 iodobenzene 

Downstream Products

• 1454818-86-0 4-[4-(phenylethynyl)phenyl]morpholine 
• 477941-30-3 3-(4-morpholin-4-yl-phenyl)-prop-2-yn-1-ol 

Relevant articles and documents

FLUORESCENT SYSTEMS FOR BIOLOGICAL IMAGING AND USES THEREOF

The invention relates to compounds of formula I, in which Y, Ar1, Ar2, X, R1 and R2 are defined herein, and to their use in a variety of biological imaging techniques and therapeutic methods. In aspects, the invention relates to conjugates comprising the compounds of formula I and their associated uses and therapeutic uses.

Arene diazonium saccharin intermediates: A greener and cost-effective alternative method for the preparation of aryl iodide

In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a) included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates, and (d) avoid the generation of heavy metal or corrosive waste.

A facile and sustainable protocol to the preparation of aryl iodides using stable arenediazonium bis(trifluoromethylsulfonyl)imide salts via the telescopic process

The preparation of aryl iodides in a telescopic reaction using tert-butyl nitrite as a diazotization reagent and a mixture of bis(trifluoromethane) sulfonamide and glacial acetic acid as a mild acidic agent in ethanol followed by iododediazoniation with tetraethylammonium iodide in water was investigated. The current method has other advantages such as minimized waste by avoiding solvent for the purification of products in diazotization step, simple experimental procedure, and good yield of the sterically hindered aryl amines, metal and strong acid-free waste and environmentally benign conditions. The noteworthy features of this study are the preparation of stable arenediazonium bis(trifluoromethylsulfonyl)imide salts that can be used with no significant loss activity after 1?week and bis(trifluoromethane)sulfonamide was recovered in high yields from reactions.