Technology Process of (S)-N-[4-[[(2-AMino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid
There total 24 articles about (S)-N-[4-[[(2-AMino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen; silica gel; (2S,4S)-N-butoxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine;
chloro(1,5-cyclooctadiene)rhodium(I) dimer;
In
phosphate buffer;
at 80 ℃;
for 24h;
under 37503 Torr;
pH=7.0;
Further Variations:;
Reagents;
Product distribution;
DOI:10.1007/s007060070017
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 77 percent / 50 percent NaOH, sodium dithionite / H2O / 3.33 h / Ambient temperature
2: NaOH, EDTA, MgCl2*6H2O, dithiotreitol, adenosine triphosphate, glucose hydrate, NADP(1+), diammonium acetyl phosphate / H2O / 168 h / Ambient temperature; protection from light; enzyme-catalyzed reduction with dihydrofolate reductase, glucose 6-phosphate dehydrogenase hexokinase and acetate kinase
With
sodium hydroxide; sodium dithionite; D-glucose monohydrate; ethylenediaminetetraacetic acid; ethanoylphosphate diammonium salt; nicotinamide adenine dinucleotide phosphate; ATP; magnesium chloride; diothiothreitol;
In
water;
DOI:10.1016/S0040-4020(01)87409-3
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / aq. 1 M HCl / tetrahydrofuran / 2.5 h / 58 °C
2: 91 percent / hydrogen / 10percent Pd-C / dimethylformamide; aq. HCl / 25 h / 2327.2 Torr
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; hydrogenchloride; N,N-dimethyl-formamide;
DOI:10.1021/jo00042a030
