Levomefolic Acid

Base Information

• Chemical Name: Levomefolic Acid
• CAS No.: 31690-09-2
• Molecular Formula: C20H25N7O6
• Molecular Weight: 459.462
• Mol file: 31690-09-2.mol

Synonyms:Glutamicacid, N-[p-[[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-5-methyl-6-pteridinyl)methyl]amino]benzoyl]-,L-(-)- (8CI);L-Glutamic acid,N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-,(S)-;L-Glutamic acid, N-[4-[[[(6S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-(9CI);(6S)-5-Methyltetrahydrofolic acid;L-Glutamic acid,N-[4-[[[(6S)-2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-;LMSR;Levomefolic acid;l-N5-Methyl-L-tetrahydrofolic acid;

Chemical Property of Levomefolic Acid

Chemical Property:

• PKA: 3.51±0.10(Predicted)
• PSA: 202.77000
• Density: 1.62 g/cm³
• LogP: 0.99040
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Aqueous Base (Slightly, Heated, Sonicated), DMSO (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Levomefolic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Levomefolic Acid is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.
• Uses: As a natural, active form of folic acid, Levomefolic Acid can be used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supple A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.

Technology Process of Levomefolic Acid

There total 11 articles about Levomefolic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

calcium 5-methyl-(6S)-tetrahydrofolic acid 6(S)-5-methyl tetrahydrofolate → (6S)-N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-4-oxo-5-methyl-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid (31690-09-2)

Guidance literature:

With sodium dithionite; disodium ethylenediaminetetraacetic acid; acetic acid; In water; at 45 ℃; pH=4.3 - 5.5;

Reference yield:

5-methyl-(6RS)-tetrahydrofolic acid → (6S)-N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-4-oxo-5-methyl-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid (31690-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1: water / 25 - 70 °C

2: water / 25 - 70 °C / Resolution of racemate

3: hydrogenchloride / water / 25 - 30 °C / pH 5 - 7.6

With hydrogenchloride; In water;

Reference yield:

N-octyl-D-glucamine salt 5-methyl-(6RS)-tetrahydrofolic acid → (6S)-N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-4-oxo-5-methyl-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid (31690-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 25 - 70 °C / Resolution of racemate

2: hydrogenchloride / water / 25 - 30 °C / pH 5 - 7.6

With hydrogenchloride; In water;

upstream raw materials:

folate

formaldehyd

ammonium hydroxide

(6S,S)-5,6,7,8-tetrahydrofolic acid

Refernces

• 1、 -. "Preparation method of L-5-calcium methyltetrahydrofolate". . . Retrieved 2018/07/07.
• 2、 -. "RESOLUTION OF TETRAHYDROFOLIC ACID DERIVATIVES". . . Retrieved 2013/03/26.