Acetic acid 3,4-dimethoxyphenyl ester

Base Information

• Chemical Name: Acetic acid 3,4-dimethoxyphenyl ester
• CAS No.: 7203-46-5
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Mol file: 7203-46-5.mol

Synonyms:4-acetoxy-1,2-dimethoxy-benzene;3,4-dimethoxy phenyl acetate;Essigsaeure-(3.4-dimethoxy-phenylester);3,4-dimethoxyphenylacetate;4-Acetoxy-1,2-dimethoxy-benzol;3,4-dimethoxyphenyl acetate;

Chemical Property of Acetic acid 3,4-dimethoxyphenyl ester

Chemical Property:

• PSA: 44.76000
• LogP: 1.62910

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid 3,4-dimethoxyphenyl ester

There total 16 articles about Acetic acid 3,4-dimethoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-dimethoxyphenol (2033-89-8) + acetic anhydride (108-24-7) → 3,4-dimethoxyphenyl acetate (7203-46-5)

Guidance literature:

With dmap; at 70 ℃; for 12h; Inert atmosphere;

DOI:10.1002/hlca.201000306

Reference yield: 87.0%

1,2-dimethoxybenzene (91-16-7) + acetic acid (64-19-7,77671-22-8) → 3,4-dimethoxyphenyl acetate (7203-46-5)

Guidance literature:

With sodium nitrate; acetic anhydride; trifluoroacetic acid; at 20 ℃; for 14h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02183

Reference yield: 67.0%

1,2-dimethoxybenzene (91-16-7) + [bis(acetoxy)iodo]benzene (3240-34-4) → 3,4-dimethoxyphenyl acetate (7203-46-5)

Guidance literature:

With chloro{1-tert-butyl-3-[(p-tolylsulfinyl)methyl]imidazol-2-ylidene}palladium(II); In acetic anhydride; acetic acid; at 95 ℃; for 16h; Sealed tube;

DOI:10.1021/om400981x

upstream raw materials:

3,4-dimethoxyphenol

acetic anhydride

peracetic acid

toluene-4-sulfonic acid

Downstream raw materials:

3,4-dimethoxyphenyl (2E)-3-(dimethylamino)prop-2-enoate

Scoparone

6,7-dimethoxy-4-methylcoumarin

2-hydroxy-4,5-dimethoxyacetophenone

Refernces

• 1、 Jennings, John A.,Parkin, Sean,Munson, Eric,Delaney, Sean P.,Calahan, Julie L.,Isaacs, Mark,Hong, Kunlun,Crocker, Mark. "Regioselective Baeyer-Villiger oxidation of lignin model compounds with tin beta zeolite catalyst and hydrogen peroxide". . p. 25987 - 25997. Retrieved 2017/07/07.
• 2、 Gadakh, Sunita K.,Dey, Soumen,Sudalai, Arumugam. "Rh-Catalyzed Synthesis of Coumarin Derivatives from Phenolic Acetates and Acrylates via C-H Bond Activation". . p. 11544 - 11550. Retrieved 2015/12/04.