3,4-Dimethoxyphenol

Base Information

• Chemical Name: 3,4-Dimethoxyphenol
• CAS No.: 2033-89-8
• Molecular Formula: C8H10O3
• Molecular Weight: 154.166
• Hs Code.: 2909500000
• European Community (EC) Number: 217-995-4
• NSC Number: 140927
• UNII: 38B43WCU83
• DSSTox Substance ID: DTXSID7062112
• Nikkaji Number: J139.789C
• Wikidata: Q27256773
• Mol file: 2033-89-8.mol

Synonyms:3,4-DIMETHOXYPHENOL;2033-89-8;Phenol, 3,4-dimethoxy-;3,4-Bis(methyloxy)phenol;3,4-dimethoxy phenol;UNII-38B43WCU83;38B43WCU83;EINECS 217-995-4;MFCD00008390;4-Hydroxyveratrole;NSC 140927;NSC-140927;3,4-dimethoxyphel;NSC140927;3,4,dimethoxyphenol;Phenol,4-dimethoxy-;3,4-dimethoxy-phenol;3, 4-dimethoxy phenol;O(C)c1ccc(O)cc1OC;3 pound not4-dimethoxyphenol;3,4-Dimethoxyphenol, 97%;SCHEMBL119396;1-hydroxy-3,4-dimethoxybenzene;DTXSID7062112;CS-B1823;HY-N1780;STR06225;AKOS005146109;AC-3793;AM61832;SY017636;TS-02054;A4425;D3221;FT-0614348;EN300-91592;AE-508/42302277;Q-101910;Q27256773;Z1255434752

Chemical Property of 3,4-Dimethoxyphenol

Chemical Property:

• Appearance/Colour: Red crystal powder
• Vapor Pressure: 0.00394mmHg at 25°C
• Melting Point: 79-82 °C(lit.)
• Refractive Index: 1.522
• Boiling Point: 271.2 °C at 760 mmHg
• Flash Point: 117.8 °C
• PSA: 38.69000
• Density: 1.134 g/cm³
• LogP: 1.40940
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 154.062994177
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)O)OC

Technology Process of 3,4-Dimethoxyphenol

There total 56 articles about 3,4-Dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-dimethoxyphenyl formate (2033-88-7) → 3,4-dimethoxyphenol (2033-89-8)

Guidance literature:

With water; potassium carbonate; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/hlca.201000306

Reference yield: 96.0%

methanol (67-56-1) + 2-hydroxy-1-(2-methoxyphenoxy)ethyl 3,4-dimethoxybenzoate → 3,4-dimethoxyphenol (2033-89-8)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 6h;

Reference yield: 96.0%

methanol (67-56-1) + 3,4-dimethoxyphenyl 3-hydroxy-2-(2-methoxyphenoxy)propanoate → 3,4-dimethoxyphenol (2033-89-8)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 6h;

upstream raw materials:

3,4-dimethoxyphenyl acetate

3,4-dimethoxyphenyl formate

2-hydroxy-4,5-dimethoxybenzoic acid

3,4-dimethoxyaniline

Downstream raw materials:

4,5-Dimethoxy-2-piperidinomethyl-phenol

1-(2-hydroxy-4,5-dimethoxyphenyl)butan-1-one

2,2,2-trifluoro-1-(2-hydroxy-4,5-dimethoxy-phenyl)-ethanone

2-benzoyloxy-1-(2-hydroxy-4,5-dimethoxy-phenyl)-ethanone

Refernces

• 1、 Clark. "-". . p. 3431,3433. Retrieved 1931.
• 2、 Dong, Zhenhua,Liu, Mengmeng,Pan, Hongguo. "Catalyst-free rapid conversion of arylboronic acids to phenols under green condition". . . Retrieved 2021/09/06.
• 3、 Cheng, Xi-Chuang,Guo, Xin-Ran,Liu, Hua-Min,Liu, Yu-Lan,Qin, Zhao,Wang, Xue-De. "Structural features and antioxidant activities of Chinese quince (Chaenomeles sinensis) fruits lignin during auto-catalyzed ethanol organosolv pretreatment". . p. 4348 - 4358. Retrieved 2020/09/22.