Dimorpholinophosphinyl chloride

Base Information

• Chemical Name: Dimorpholinophosphinyl chloride
• CAS No.: 7264-90-6
• Molecular Formula: C8H16ClN2O3P
• Molecular Weight: 254.653
• UNII: AA8L9ZYV2G
• DSSTox Substance ID: DTXSID90500726
• Nikkaji Number: J761.252D
• Wikidata: Q82352594
• Mol file: 7264-90-6.mol

Synonyms:7264-90-6;Dimorpholinophosphinyl chloride;4-[chloro(morpholin-4-yl)phosphoryl]morpholine;dimorpholinophosphinic chloride;AA8L9ZYV2G;bis(morpholin-4-yl)phosphinoyl chloride;Phosphinic chloride, di-4-morpholinyl-;Bis(morpholino)phosphinyl chloride;P,P-Di-4-morpholinylphosphinic chloride;Phosphinic chloride, P,P-di-4-morpholinyl-;UNII-AA8L9ZYV2G;SCHEMBL2844045;DTXSID90500726;XTOQMDCHFVDCCL-UHFFFAOYSA-N;di-4-morpholinylphosphinic chloride;AT25600;Bis[(morpholin-4-yl)]phosphinic chloride;bis-(4-morpholinyl)phosphinic acid chloride

Chemical Property of Dimorpholinophosphinyl chloride

Chemical Property:

• Melting Point: 80 °C
• Boiling Point: 137-140 °C(Press: 0.02 Torr)
• PKA: -3.02±0.20(Predicted)
• PSA: 51.82000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 0.87350
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 254.0587071
• Heavy Atom Count: 15
• Complexity: 232

Purity/Quality:

99%, ^*data from raw suppliers

DimorpholinophosphinylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1P(=O)(N2CCOCC2)Cl
• Uses: Dimorpholinophosphinyl Chloride is an condensing reagent in the synthesis of Dexamethasone Phosphate (D298835), a pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid.

Technology Process of Dimorpholinophosphinyl chloride

There total 6 articles about Dimorpholinophosphinyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimorpholylmethane (22630-09-7) + morpholinophosphonic dichloride (1498-57-3) → di-morpholin-4-yl-phosphinic acid chloride (7264-90-6)

Guidance literature:

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) + morpholinophosphonic dichloride (1498-57-3) → di-morpholin-4-yl-phosphinic acid chloride (7264-90-6)

Guidance literature:

With triethylamine; In diethyl ether; at -15 ℃; for 24h;

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) → di-morpholin-4-yl-phosphinic acid chloride (7264-90-6)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

morpholine

morpholinophosphonic dichloride

trimorpholylmethane

trichlorophosphate

Downstream raw materials:

tris(morpholino)phenylphosphine oxide

di-morpholin-4-yl-phosphinic acid 7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl ester

3-acetossi-7-cloro-5-fenil-2-(di-4-morfolinil)fosfinilossi-3H-1,4-benzodiazepina

5-chloro-2-(2-chloro-acetylamino)-N-(di-morpholin-4-yl-phosphinoyl)-benzamide

Refernces

• 1、 -. "Preparation method of benzodiazepine derivatives". Paragraph 0050-0051; 0087; 0089; 0091. . Retrieved 2018/07/30.
• 2、 Cremlyn, Richard J.,Patel, Kantilal,Wu, Luke. "Some Derivatives of Morpholinophosphorodichloridate and dichloridothioate". . p. 1457 - 1464. Retrieved 2007/10/02.