4-(2H-TETRAZOL-5-YL)-PYRIDINE

Base Information

• Chemical Name: 4-(2H-TETRAZOL-5-YL)-PYRIDINE
• CAS No.: 33893-89-9
• Molecular Formula: C6H5N5
• Molecular Weight: 147.139
• Hs Code.: 2933990090
• Mol file: 33893-89-9.mol

Synonyms:Pyridine,2-(1H-tetrazol-5-yl)- (8CI,9CI);Pyridine, 2-(tetrazol-5-yl)- (6CI);2-(1H-Tetrazol-5-yl)pyridine;2-(5-Tetrazolyl)pyridine;5-(2-Pyridinyl)tetrazole;Pyridine,2-(2H-tetrazol-5-yl)-;5-(2-Pyridyl)-2H-tetrazole;5-(2-Pyridyl)tetrazole;5-(Pyridin-2-yl)-1H-tetrazole;NSC 267037;

Chemical Property of 4-(2H-TETRAZOL-5-YL)-PYRIDINE

Chemical Property:

• Vapor Pressure: 6.9E-06mmHg at 25°C
• Melting Point: 214-215 ºC
• Boiling Point: 390.341 °C at 760 mmHg
• PKA: 6.66±0.19(Predicted)
• Flash Point: 198.684 °C
• PSA: 67.35000
• Density: 1.389 g/cm³
• LogP: 0.26170
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water at 25°C 11 g/L.

Purity/Quality:

99%, ^*data from raw suppliers

2-(1H-Tetrazol-5-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-36-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used in the synthesis and crystal structure of the [Ag(2-allyl-5-phenyl-2Htetrazole)ClO4] π,?-complex .

Technology Process of 4-(2H-TETRAZOL-5-YL)-PYRIDINE

There total 17 articles about 4-(2H-TETRAZOL-5-YL)-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Cyanopyridine (100-70-9,1232006-36-8) → 5-(2-pyridyl)-1H-tetrazole (33893-89-9)

Guidance literature:

With sodium azide; water; zinc(II) chloride; at 25 ℃; for 24h; Micellar solution;

DOI:10.1002/ejoc.201301364

Reference yield: 96.0%

potassium cyanide + pyridin-2-ylboronic acid (197958-29-5) → 5-(2-pyridyl)-1H-tetrazole (33893-89-9)

Guidance literature:

With sodium azide; potassium carbonate; In ethanol; water; for 5h; Catalytic behavior; Reflux; Inert atmosphere; Green chemistry;

DOI:10.1016/j.mcat.2021.111489

Reference yield: 95.0%

2-Hydroxymethylpyridine (586-98-1) → 5-(2-pyridyl)-1H-tetrazole (33893-89-9)

Guidance literature:

With sodium azide; hydroxylamine hydrochloride; In water; at 20 ℃; for 2.41667h;

DOI:10.1016/j.mcat.2020.111311

upstream raw materials:

2-Cyanopyridine

pyridine-2-carboxamidrazone

hydrogenchloride

2-bromo-pyridine

Downstream raw materials:

mesitylenesulfonyl 5-(pyridin-2-yl) tetrazolide

2,4,6-triisopropylbenzenesulfonyl 5-(pyridin-2-yl) tetrazolide

2-(2-methyl-2H-tetrazol-5-yl)pyridine

2-(1-methyl-1H-tetrazol-5-yl)pyridine

Refernces

• 1、 Dragonetti, Claudia,Colombo, Alessia,Magni, Mirko,Mussini, Patrizia,Nisic, Filippo,Roberto, Dominique,Ugo, Renato,Valore, Adriana,Valsecchi, Arianna,Salvatori, Paolo,Lobello, Maria Grazia,Angelis, Filippo De. "Thiocyanate-free ruthenium(II) sensitizer with a pyrid-2-yltetrazolate ligand for dye-sensitized solar cells". . p. 10723 - 10725. Retrieved 2013.
• 2、 Giridhar, Thota,Cho, Woosum,Gal, Yeong-Soon,Lee, Jae Wook,Jin, Sung-Ho. "Synthesis and Characterization of New Phosphorescent Heteroleptic Iridium (III) Complex by Using Tetrazole as an Ancillary Ligand for Organic Light-Emitting Diodes". . p. 17 - 25. Retrieved 2015.
• 3、 Surendra Babu,Santhosh Reddy,Ghosh, Kalyan Sundar,Sahoo, Bijaya Ketan,Himasekar,Mustafa, Shaik. "Design, Synthesis, Single X-Ray Crystal Structure, DFT and Molecular Docking Studies of Novel Clip Type-Pyridyltetrazole Analogues". . p. 333 - 342. Retrieved 2018.
• 4、 Mustafa, Shaik,Rao, Bommuluri Umamaheswara,SurendraBabu, Manubolu Surya,Raju, Kalidindi Krishnam,Rao, Gollapalli Nageswara. "Synthesis, Characterization, and Biological Activities of Pendant Arm-Pyridyltetrazole Copper(II) Complexes: DNA Binding/Cleavage Activity and Cytotoxic Studies". . p. 1516 - 1534. Retrieved 2015.
• 5、 Mal, Suraj,Pietraszkiewicz, Marek,Pietraszkiewicz, Oksana. "Strongly photoluminescent Eu(III) tetrazolate ternary complexes with phosphine oxides as powerful sensitizers". . p. 367 - 377. Retrieved 2015.
• 6、 Zhao, Yuqing,Van, Yilei,Wang, Di,Li, Lihua,Qiu, Pan. "Polymer immobilization effect on excited state of emitting copper complex: Synthesis, characterization and performance improvement". . p. 171 - 178. Retrieved 2019.
• 7、 Bond, Andrew D.,Fleming, Adrienne,Gaire, Jackie,Kelleher, Fintan,McGinley, John,McKee, Vickie,Sheridan, Ursula. "Coordination studies of copper(II), cobalt(II) and iron(II) with isomeric pyridyl-tetrazole ligands". . p. 289 - 296. Retrieved 2012.
• 8、 Rao, B. Umamaheswara,Krishna,Rao, G. Nageswara. "Synthesis, characterization and antimicrobial activity of isomeric pyridyl-tetrazole derivative ligands and their bivalent metal complexes". . p. 4405 - 4410. Retrieved 2015.
• 9、 Darkwa, James,Makhubela, Banothile C. E.,Ocansey, Edward. "Iridium and Palladium CO2Hydrogenation in Water by Catalyst Precursors with Electron-Rich Tetrazole Ligands". . p. 3088 - 3098. Retrieved 2020.
• 10、 Tahmasbi, Marzieh,Akbarzadeh, Parisa,Koukabi, Nadiya. "Magnetic nitrogen-doped carbon derived from silk cocoon biomass: a promising and sustainable support for copper". . p. 1383 - 1401. Retrieved 2021/12/01.