Tedizolid Impurity 39

Base Information

• Chemical Name: Tedizolid Impurity 39
• CAS No.: 171018-17-0
• Molecular Formula: C₇H₇N₅
• Molecular Weight: 161.166
• Mol file: 171018-17-0.mol

Synonyms:

Chemical Property of Tedizolid Impurity 39

Chemical Property:

• Boiling Point: 349.7±34.0 °C(Predicted)
• PKA: 0.89±0.10(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tedizolid Impurity 39

There total 3 articles about Tedizolid Impurity 39 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

5-(2-pyridyl)-1H-tetrazole (33893-89-9) + methyl iodide (74-88-4) → 2-(2-methyl-2H-tetrazol-5-yl)pyridine (171018-17-0) + 2-(1-methyl-1H-tetrazol-5-yl)pyridine (171018-16-9)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1002/chem.201701862

Reference yield: 20.0%

5-(2-pyridyl)-1H-tetrazole (33893-89-9) + methyl iodide (74-88-4) → 2-(2-methyl-2H-tetrazol-5-yl)pyridine (171018-17-0)

Guidance literature:

With potassium carbonate; In acetonitrile; for 24h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1002/aoc.5806

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → 2-(2-methyl-2H-tetrazol-5-yl)pyridine (171018-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; zinc dibromide / water / 24 h / Reflux

2: sodium hydroxide / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium azide; sodium hydroxide; zinc dibromide; In water; N,N-dimethyl-formamide;

DOI:10.1002/chem.201701862

upstream raw materials:

5-(2-pyridyl)-1H-tetrazole

methyl iodide

2-Cyanopyridine

Refernces

• 1、 Monti, Nicola,Longo, Veronica,Zacchini, Stefano,Vigarani, Giulia,Giorgini, Loris,Bonora, Eugenia,Massi, Massimiliano,Fiorini, Valentina,Stagni, Stefano. "Alkyl tetrazoles as diimine (“diim”) ligands for fac-[Re(diim)(CO)3(L)]-type complexes. Synthesis, characterization and preliminary studies of the interaction with bovine serum albumin". . . Retrieved 2021/02/05.
• 2、 Downard, Alison J.,Steel, Peter J.,Steenwijk, Jonathan. "Syntheses of Chelating Tetrazole-Containing Ligands and Studies of Their Palladium(II) and Ruthenium(II) Complexes". . p. 1625 - 1642. Retrieved 2007/10/03.