2,4-Dihydroxy-5-Methoxyacetophenone

Base Information

• Chemical Name: 2,4-Dihydroxy-5-Methoxyacetophenone
• CAS No.: 7298-21-7
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• Hs Code.: 2914500090
• Mol file: 7298-21-7.mol

Synonyms:

Chemical Property of 2,4-Dihydroxy-5-Methoxyacetophenone

Chemical Property:

• Melting Point: 166 °C
• Boiling Point: 333.9±22.0 °C(Predicted)
• PKA: 7.98±0.23(Predicted)
• Density: 1.284±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dihydroxy-5-methoxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,4-Dihydroxy-5-methoxyacetophenone (cas# 7298-21-7) is a compound useful in organic synthesis.

Technology Process of 2,4-Dihydroxy-5-Methoxyacetophenone

There total 12 articles about 2,4-Dihydroxy-5-Methoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

boron trifluoride diethyl etherate (109-63-7) + 3-acetoxy-4-methoxyphenol (99179-72-3) → 1-(2,4-dihydroxy-5-methoxyphenyl)ethan-1-one (7298-21-7)

Guidance literature:

at 70 ℃; for 2h;

Reference yield: 86.0%

4-methoxybenzene-1,3-diol (6100-60-3) + acetyl chloride (75-36-5) → 1-(2,4-dihydroxy-5-methoxyphenyl)ethan-1-one (7298-21-7)

Guidance literature:

With boron trifluoride diethyl etherate; for 3h; Inert atmosphere;

DOI:10.1007/s00044-019-02320-w

Reference yield: 77.0%

4-methoxybenzene-1,3-diol (6100-60-3) + acetic acid (64-19-7,77671-22-8) → 1-(2,4-dihydroxy-5-methoxyphenyl)ethan-1-one (7298-21-7)

Guidance literature:

With boron trifluoride diethyl etherate; at 20 - 120 ℃; for 12h; Inert atmosphere;

upstream raw materials:

2,4-diacetoxy-1-methoxy-benzene

4-methoxybenzene-1,3-diol

acetonitrile

3-acetoxy-4-methoxyphenol

Downstream raw materials:

3-(benzo[d][1,3]dioxol-5-yl)-7-(benzyloxy)-6-methoxy-4H-chromen-4-one

Refernces

• 1、 Mendieta-Moctezuma, Aarón,Rugerio-Escalona, Catalina,Villa-Ruano, Nemesio,Gutierrez, Rsuini U.,Jiménez-Montejo, Fabiola E.,Fragoso-Vázquez, M. Jonathan,Correa-Basurto, José,Cruz-López, María C.,Delgado, Francisco,Tamariz, Joaquín. "Synthesis and biological evaluation of novel chromonyl enaminones as α-glucosidase inhibitors". . p. 831 - 848. Retrieved 2019/04/25.
• 2、 Hayakawa, Ichiro,Shioda, Shuya,Ikedo, Akiyuki,Kigoshi, Hideo. "Practical synthesis of glaziovianin A, a cytotoxic isoflavone, and its O7-propargyl analogue". . p. 544 - 549. Retrieved 2014/05/06.