99179-72-3Relevant articles and documents
The synthesis of [2,3,4-13C3]glycitein
Zhang, Qingzhi,Botting, Nigel P.
, p. 12211 - 12216 (2007/10/03)
Glycitein is one of the soy isoflavones which have attracted considerable interest in recent years due to their possible beneficial effects on human health. However, glycitein has been much less studied than other members of this family due to the lack of
Mechanistic Studies of Selective Catechol Formation from o-Methoxyphenols using a Copper(II)-Ascorbic Acid-Dioxygen System
Aihara, Kazuhiro,Urano, Yasuteru,Higuchi, Tsunehiko,Hirobe, Masaaki
, p. 2165 - 2170 (2007/10/02)
Mechanistic details of selective conversion of o-methoxyphenols to the corresponding catechols using a Cu2+-ascorbic acid-O2 system, were studied. 2,5-Dimethoxyphenol was converted predominantly to the o-demethylated compound and partially to the m-demethylated one.Anisole with no phenolic hydroxy group was much less reactive.When guaiacol (1). guaiacol and 2-methoxy-6-methoxyphenol was used as substrates, moderate intermolecular and intramolecular kinetic isotope effects were observed (1.4-1.9). Catechol was derived from 1 in nine-fold excess over catechol when the reaction was run in an 18O2 atmosphere with natural water as a solvent, though no catechol was formed when using natural O2 and H218O.It was determined that the Cu2+-ascorbic acid-O2 system operates in a monooxygenase mode because the oxygen atom of dioxygen (not water) was incorporated into the products, and this oxidative conversion proceeded mainly via ipso-substitution at the methoxy position, probably with hydroxyl radical coordinated to the cupric ion as the active oxygen species.