Phosphoramidic acid, [2-(6-methoxy-2-naphthalenyl)-1-(1-pyrrolidinyl)propylidene]-, diphenyl ester

Base Information

• Chemical Name: Phosphoramidic acid, [2-(6-methoxy-2-naphthalenyl)-1-(1-pyrrolidinyl)propylidene]-, diphenyl ester
• CAS No.: 73031-35-3
• Molecular Formula: C30H31N2O4P
• Molecular Weight: 514.561
• Mol file: 73031-35-3.mol

Synonyms:

Chemical Property of Phosphoramidic acid, [2-(6-methoxy-2-naphthalenyl)-1-(1-pyrrolidinyl)propylidene]-, diphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphoramidic acid, [2-(6-methoxy-2-naphthalenyl)-1-(1-pyrrolidinyl)propylidene]-, diphenyl ester

There total 2 articles about Phosphoramidic acid, [2-(6-methoxy-2-naphthalenyl)-1-(1-pyrrolidinyl)propylidene]-, diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-2-propionylnaphthalene (2700-47-2) → diphenyl N-<2-(6-methoxy-2-naphthyl)-1-pyrrolidinopropylidene>phosphoramidate (73031-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / boron trifluoride etherate/molecular sieve 4A / benzene / 68 h / Heating

2: 65 percent / tetrahydrofuran / RT, 1 h; 40 deg C, 2 h; 50 deg C, 1 h

With 4 A molecular sieve; boron trifluoride diethyl etherate; In tetrahydrofuran; benzene;

DOI:10.1248/cpb.31.3139

Reference yield:

pyrrolidine (123-75-1) + diphenyl phosphoryl azide (26386-88-9) + 6-methoxy-2-propionylnaphthalene (2700-47-2) → diphenyl N-<2-(6-methoxy-2-naphthyl)-1-pyrrolidinopropylidene>phosphoramidate (73031-35-3)

Guidance literature:

With 4 A molecular sieve; boron trifluoride diethyl etherate; Yield given. Multistep reaction; 1.) benzene, reflux, 50 h; 2.) THF, RT, 1 h; 40 deg C, 1 h; reflux, 2 h;

DOI:10.1248/cpb.31.3139

Reference yield: 71.0%

diphenyl N-<2-(6-methoxy-2-naphthyl)-1-pyrrolidinopropylidene>phosphoramidate (73031-35-3) → naproxen (23981-80-8)

Guidance literature:

With potassium hydroxide; In ethylene glycol; for 8h; Heating;

DOI:10.1248/cpb.31.3139

upstream raw materials:

pyrrolidine

diphenyl phosphoryl azide

6-methoxy-2-propionylnaphthalene

Downstream raw materials:

naproxen

Refernces