N-BENZYL 4-BROMOBENZENESULFONAMIDE

Base Information

• Chemical Name: N-BENZYL 4-BROMOBENZENESULFONAMIDE
• CAS No.: 3609-87-8
• Molecular Formula: C13H12BrNO2S
• Molecular Weight: 326.214
• Hs Code.: 2935009090
• Mol file: 3609-87-8.mol

Synonyms:N-Benzyl-4-bromobenzenesulphonamide;

Chemical Property of N-BENZYL 4-BROMOBENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 3.39E-08mmHg at 25°C
• Melting Point: 102-104 °C
• Refractive Index: 1.62
• Boiling Point: 447.4 °C at 760 mmHg
• Flash Point: 224.4 °C
• PSA: 54.55000
• Density: 1.503 g/cm³
• LogP: 4.39930

Purity/Quality:

99% ^*data from raw suppliers

N-Benzyl4-bromobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BENZYL 4-BROMOBENZENESULFONAMIDE

There total 8 articles about N-BENZYL 4-BROMOBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzylamine (100-46-9) + 4-bromobenzenesulfonyl chloride (98-58-8) → Ν-benzyl-4-bromobenzenesulfonamide (3609-87-8)

Guidance literature:

With triethylamine; In dichloromethane; 1) 0 deg C, 1 h, 2) room temperature;

DOI:10.1039/P19950002025

Reference yield: 98.0%

(E)-N-benzylidene-4-bromobenzenesulfonamide → Ν-benzyl-4-bromobenzenesulfonamide (3609-87-8)

Guidance literature:

With methanol; potassium tert-butylate; bis(pinacol)diborane; copper(l) chloride; In tetrahydrofuran; at 20 ℃; for 12h; Reagent/catalyst; Catalytic behavior; Mechanism; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2021.132063

Reference yield: 96.0%

4-bromo-benzenesulfonic acid amide (701-34-8) + benzyl alcohol (100-51-6,185532-71-2) → Ν-benzyl-4-bromobenzenesulfonamide (3609-87-8)

Guidance literature:

With air; copper diacetate; potassium carbonate; at 150 ℃; for 12h;

DOI:10.1002/anie.200901510

upstream raw materials:

benzylamine

4-bromobenzenesulfonyl chloride

4-bromo-benzenesulfonic acid ethyl ester

4-bromo-benzenesulfonic acid amide

Downstream raw materials:

N-(p-bromobenzenesulfonyl)benzenealdimine

Refernces

• 1、 He, Yi,Li, Shi-Guang,Mbaezue, Ifenna I.,Reddy, Angula C.S.,Tsantrizos, Youla S.. "Copper-boryl mediated transfer hydrogenation of N-sulfonyl imines using methanol as the hydrogen donor". supporting information. . Retrieved 2021/03/24.
• 2、 Reed-Berendt, Benjamin G.,Morrill, Louis C.. "Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols". . p. 3715 - 3724. Retrieved 2019/03/30.